Evidence map›Paper›PMID 38000840›Full record

ReviewNeurosurgery clinics of North America2024

Neurostimulation for Generalized Epilepsy: Should Therapy be Syndrome-specific?

Aaron E L Warren, Steven Tobochnik, Melissa M J Chua, Hargunbir Singh, Michaela A Stamm, John D Rolston

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgery clinics of North America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaron E L WarrenDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: awarren15@bwh.harvard.edu.
Steven TobochnikDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Melissa M J ChuaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hargunbir SinghDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michaela A StammDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John D RolstonDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for EpilepsyK23NS114178 · NINDS · UNIVERSITY OF UTAH · PI ROLSTON, JOHN D · 2019 to 2023
$961k
NINDS NIH HHS K23 NS114178
6 · The paper itself

Abstract

Current applications of neurostimulation for generalized epilepsy use a one-target-fits-all approach that is agnostic to the specific epilepsy syndrome and seizure type being treated. The authors describe similarities and differences between the 2 "archetypes" of generalized epilepsy-Lennox-Gastaut syndrome and Idiopathic Generalized Epilepsy-and review recent neuroimaging evidence for syndrome-specific brain networks underlying seizures. Implications for stimulation targeting and programming are discussed using 5 clinical questions: What epilepsy syndrome does the patient have? What brain networks are involved? What is the optimal stimulation target? What is the optimal stimulation paradigm? What is the plan for adjusting stimulation over time?

Indexed as

Deep Brain StimulationEpilepsyEpilepsy, GeneralizedEpileptic SyndromesBrainHumansDeep brain stimulationEpilepsyGeneralized seizuresIdiopathic generalized epilepsyLennox-Gastaut syndromeNeuromodulationResponsive neurostimulationThalamus

Identifiers

PMID38000840
PMCPMC10676463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.