Evidence map›Paper›PMID 38000812›Full record

ReviewBMJ case reports2023

Periportal necrosis and successful liver transplantation following Lamotrigine drug-induced liver injury in a child.

Michael Richard Couper, Rachel M Brown, Stuart Nath, Amitav Parida, Chayarani Kelgeri

Open access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMJ case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Drug-Induced Liver Injury-Pharmacological Spectrum Among Children.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael Richard CouperLiver unit, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.ORCID http://orcid.org/0000-0002-1564-279X
Rachel M BrownHistopathology, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
Stuart NathPaediatric division, Royal Cornwall Hospitals NHS Trust, Truro, UK.
Amitav ParidaNeurology, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
Chayarani KelgeriLiver unit, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK chayarani.kelgeri@nhs.net.ORCID http://orcid.org/0000-0002-0112-2945
Birmingham Children's Hospital · GBRoyal Cornwall Hospital Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lamotrigine is one of the most prescribed antiepileptics in children and a well-known cause of drug-induced liver injury (DILI). The typical presentation usually includes a drug rash with eosinophilia and systemic symptoms (DRESS syndrome). Cases are typically mild and self-limiting, requiring supportive care only. We report a severe Lamotrigine-induced DILI with a non-typical presentation with hyperammonaemia and rapid clinical deterioration. We present a literature review exploring contributing factors, transplant considerations and liver histology. Histology showed periportal necrosis, which is recognised as a pattern of DILI but has not been previously described with Lamotrigine. Our patient proceeded to transplant and is the first reported liver transplant for Lamotrigine DILI in a child. A directed and rapid diagnostic approach is crucial to avoid delays and rule out multisystemic metabolic and genetic conditions that preclude liver transplantation.

Indexed as

Chemical and Drug Induced Liver InjuryDrug Hypersensitivity SyndromeLiver TransplantationAnticonvulsantsChildHumansLamotrigineNecrosisAnticonvulsantsLamotrigineGastrointestinal systemHepatitis otherPaediatricsPaediatrics (drugs and medicines)

Identifiers

PMID38000812
PMCPMC10679976
OpenAlexW4388980137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.