Evidence map›Paper›PMID 38000559›Full record

ArticleBiochemical pharmacology2024

Adaptive changes in tumor cells in response to reductive stress.

Leilei Zhang, Jie Zhang, Zhi-Wei Ye, Aslam Muhammad, Li Li, John W Culpepper, Danyelle M Townsend, Kenneth D Tew

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. SENP1 inhibits aerobic glycolysis in AβCell biology and toxicology · 2025
    Article
  4. Article
  5. Redox pathways in melanoma.Advances in cancer research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Leilei ZhangDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA.
Jie ZhangDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA.
Zhi-Wei YeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA.
Aslam MuhammadDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA.
Li LiDepartment of Drug Discovery and Experimental Sciences, Medical University of South Carolina, 274 Calhoun Street MSC 141, Charleston, S.C. 29425-1410, USA.
John W CulpepperDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA.
Danyelle M TownsendDepartment of Drug Discovery and Experimental Sciences, Medical University of South Carolina, 274 Calhoun Street MSC 141, Charleston, S.C. 29425-1410, USA.
Kenneth D TewDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 70 President St., DD410, Charleston, SC 29425, USA. Electronic address: tewk@musc.edu.
Medical University of South Carolina · US

Funding

SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HAIZHEN · 2012 to 2020
$20.2M
South Carolina COBRE in Oxidants, Redox Balance and Stress SignalingP30GM140964 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EBLEN, SCOTT T · 2021 to 2025
$6.4M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20RR024485 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2011 to 2011
$2.2M
MUSC FACIL EXPANSION &RENOV: SLE C06RR015455 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CROUCH, ROSALIE K · 2002 to 2002
$2.0M
PRECLINICAL DEVELOPMENT OF A GLUTATHIONE BASED CANCER DRUGR41CA117259 · NCI · CELLECTAR BIOSCIENCES, INC. · PI TEW, KENNETH D. · 2007 to 2007
$150k
MINIMALLY-INVASIVE SURGICAL PLANNING AND TRAINING SYSTEMR43CA086604 · NCI · CREARE, INC. · PI KYNOR, DAVID B · 2001 to 2001
$100k
NCI NIH HHS R41 CA117259NCI NIH HHS R43 CA086604NCRR NIH HHS C06 RR015455NCRR NIH HHS P20 RR024485NIGMS NIH HHS P20 GM103542NIGMS NIH HHS P30 GM140964
6 · The paper itself

Abstract

Reductive stress is characterized by an excess of cellular electron donors and can be linked with various human pathologies including cancer. We developed melanoma cell lines resistant to reductive stress agents: rotenone (ROT

Indexed as

Endoplasmic Reticulum StressUnfolded Protein ResponseCell LineHumansOxidative StressProteinsReactive Oxygen SpeciesProteinsReactive Oxygen SpeciesGlycolysisMelanoma cell linesMitochondrial morphologyReactive oxygen speciesReductive stressUnfolded protein response

Identifiers

PMID38000559
PMCPMC10895707
OpenAlexW4388894444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.