Evidence map›Paper›PMID 38000152›Full record

ArticleEpilepsy research2023

A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.

Elizabeth A Matthews, Steve Harward, Josh Marek, Nicolas D Drysdale, Elizabeth Schuetz, Kamesh Krishnamurthy, James O McNamara

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth A MatthewsDepartment of Neurobiology, Duke University, Durham, NC, USA.
Steve HarwardDepartment of Neurobiology, Duke University, Durham, NC, USA.
Josh MarekDepartment of Neurobiology, Duke University, Durham, NC, USA.
Nicolas D DrysdaleDepartment of Neurobiology, Duke University, Durham, NC, USA.
Elizabeth SchuetzDepartment of Neurobiology, Duke University, Durham, NC, USA.
Kamesh KrishnamurthyDepartment of Neurobiology, Duke University, Durham, NC, USA.
James O McNamaraDepartment of Neurobiology, Duke University, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA; Department of Neurology, Duke University, Durham, NC, USA. Electronic address: jmc@neuro.duke.edu.
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Neurotrophins and EpileptogenesisR01NS056217 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2006 to 2023
$6.7M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Cellular and Circuit Mechanisms of Temporal Lobe EpilepsyR01NS097717 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2017 to 2021
$2.2M
NINDS Research Education Programs for Residents and Fellows in NeurosurgeryR25NS065731 · NINDS · DUKE UNIVERSITY · PI FECCI, PETER, HASAN, DAVID M. · 2009 to 2023
$968k
NINDS Research Education Programs for Residents and Fellows in NeurosurgeryUE5NS065731 · NINDS · DUKE UNIVERSITY · PI FECCI, PETER, HASAN, DAVID M. · 2024 to 2024
$0k
NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449NINDS NIH HHS R01 NS056217NINDS NIH HHS R01 NS097717NINDS NIH HHS R25 NS065731NINDS NIH HHS UE5 NS065731
6 · The paper itself

Abstract

The lack of preventive and disease modifying therapies for temporal lobe epilepsy (TLE) is a major unmet medical need. Search for such therapies utilize mouse models and require detection of seizures in electroencephalography (EEG) recordings. The labor-intensive nature of reviewing EEGs spanning many weeks underscores the need for a method of automated detection. Here we report a simple automated method of detecting seizures in long term EEG recordings from electrodes implanted in the hippocampus in animal models of TLE. We utilize a 2-pronged approach that relies on the increase in power within the gamma band range (20-50hz) during the seizure followed by suppression of activity following the seizure (post-ictal suppression [PIS]). We demonstrate the utility of this method for detecting seizures in hippocampal and amygdala EEG recordings from multiple models of TLE.

Indexed as

Epilepsy, Temporal LobeAmygdalaAnimalsDisease Models, AnimalElectroencephalographyHippocampusMiceSeizuresAutomated seizure detectionPost-ictal suppressionRodent epilepsy models

Identifiers

PMID38000152
PMCPMC10842913
OpenAlexW4388487726

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.