Evidence map›Paper›PMID 38000094›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2023

Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites.

Elena Deligianni, Elisabetta Pizzi, Ioanna Kavelaki, Inga Siden-Kiamos, Filippo Umberto Sapienza, Rossella Fioravanti, Stefania Garzoli, Tomasino Pace, Marta Ponzi, Rino Ragno and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. First Evidence of Anti-Biomedicines · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Elena DeligianniInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece.
Elisabetta PizziServizio Grandi Strumentazioni e Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Ioanna KavelakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece.
Inga Siden-KiamosInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece.
Filippo Umberto SapienzaRome Center for Molecular Design-RCMD, Department of Drug Chemistry and Technology, University Sapienza of Rome, Italy.
Rossella FioravantiDepartment of Drug Chemistry and Technology, University Sapienza of Rome, Rome, Italy.
Stefania GarzoliDepartment of Drug Chemistry and Technology, University Sapienza of Rome, Rome, Italy.
Tomasino PaceDipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
Marta PonziDipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
Rino RagnoDepartment of Drug Chemistry and Technology, University Sapienza of Rome, Rome, Italy. Electronic address: rino.ragno@uniroma1.it.
Chiara CurràInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece. Electronic address: curra@imbb.forth.gr.
Sapienza University of Rome · ITFoundation for Research and Technology Hellas · GRIstituto Superiore di Sanità · ITInstitute of Molecular Biology and Biotechnology · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria, an infectious disease with a tremendous impact on human health is caused by Plasmodium parasites, and transmitted by Anopheles mosquitoes. New approaches to control the disease involve transmission blocking strategies aiming to target the parasite in the mosquito. Here, we investigated the putative inhibitory activity of essential oils and their components on the early mosquito stages of the parasite. We employed an in vitro assay of gametocyte-to-ookinete development of the rodent model parasite Plasmodium berghei combined with high content screening. 60 essential oils with known composition were tested. The results revealed that fifteen EOs had inhibitory activity. Furthermore, a machine learning approach was used to identify the putative inhibitory components. Five of the most important chemical components indicated by the machine learning-based models were actually confirmed by the experimental approach. This combined approach was used for the first time to identify the potential transmission blocking activity of essential oils and single components at the zygote and ookinete stages.

Indexed as

AnophelesMalariaParasitesAnimalsHumansPlasmodium bergheiEssential oilsMachine learningMalariaOokinete

Identifiers

PMID38000094
PMCPMC10709126
OpenAlexW4388872025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.