Evidence map›Paper›PMID 38000035›Full record

ArticleScience advances2023

Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning.

Jonas B Nilsson, Saghar Kaabinejadian, Hooman Yari, Michel G D Kester, Peter van Balen, William H Hildebrand, Morten Nielsen

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Predicting Neoantigen Immunogenicity frombioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. PepGen: conditional generation of peptides for MHC binding.Bioinformatics (Oxford, England) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonas B NilssonDepartment of Health Technology, Technical University of Denmark, DK-2800 Lyngby, Denmark.ORCID 0000-0002-1322-2644
Saghar KaabinejadianPure MHC LLC, Oklahoma City, OK, USA.ORCID 0000-0002-8434-8703
Hooman YariDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0000-0002-8285-7985
Michel G D KesterDepartment of Hematology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-8960-7348
Peter van BalenDepartment of Hematology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-9670-4664
William H HildebrandDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0000-0002-7066-4174
Morten NielsenDepartment of Health Technology, Technical University of Denmark, DK-2800 Lyngby, Denmark.ORCID 0000-0001-7885-4311

Funding

IMMUNE EPITOPE AND ANALYSIS PROGRAM: Transplantation of organs, tissues and cells 75N93019C00001 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI WILSON, STEPHEN · 2019 to 2025
$23.1M
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCEU24CA248138 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2021 to 2025
$4.6M
NCI NIH HHS U24 CA248138NIAID NIH HHS 75N93019C00001
6 · The paper itself

Abstract

Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules is crucial for rational development of immunotherapies and vaccines targeting CD4

Indexed as

Antigen PresentationHLA-DR AntigensHLA-DP AntigensHLA-DQ AntigensHumansPeptidesHLA-DP AntigensHLA-DQ AntigensHLA-DR AntigensPeptides

Identifiers

PMID38000035
PMCPMC10672173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.