Evidence map›Paper›PMID 38000031›Full record

ArticleScience advances2023

MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration.

Iris Winkler, Jan Broder Engler, Vanessa Vieira, Simone Bauer, Yi-Hsiang Liu, Giovanni Di Liberto, Katarzyna M Grochowska, Ingrid Wagner, Jasmina Bier, Lukas C Bal and 10 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. miR-146a-5p mitigates ethanol-induced neuroinflammation by targeting Btg2-dependent microglial activation.Malawi medical journal : the journal of Medical Association of Malawi · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Role of CPEBs in Learning and Memory.Journal of neurochemistry · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Blood-derived microRNAs are related to cognitive domains in the general population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  18. The neuropathobiology of multiple sclerosis.Nature reviews. Neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Iris WinklerInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0002-6900-5139
Jan Broder EnglerInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0002-3169-2076
Vanessa VieiraInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Simone BauerInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0003-1780-231X
Yi-Hsiang LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Giovanni Di LibertoDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, University of Geneva and University Hospital of Geneva, Geneva 1211, Switzerland.ORCID 0000-0001-6788-0215
Katarzyna M GrochowskaLeibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Ingrid WagnerDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, University of Geneva and University Hospital of Geneva, Geneva 1211, Switzerland.ORCID 0000-0003-4437-9799
Jasmina BierInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0003-2330-0797
Lukas C BalInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0003-4731-2311
Nicola RothammerInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Nina MeursInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0001-5366-0123
Kristof EgervariDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, University of Geneva and University Hospital of Geneva, Geneva 1211, Switzerland.ORCID 0000-0001-6763-9069
Benjamin SchattlingInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0001-8809-9073
Gabriela SalinasInstitut of Human Genetics, NGS Integrative Genomics, University Medical Center Göttingen, Göttingen 37077, Germany.
Michael R KreutzLeibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Yi-Shuian HuangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0001-9000-7748
Ole PlessFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Hamburg 22525, Germany.ORCID 0000-0002-1468-316X
Doron MerklerDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, University of Geneva and University Hospital of Geneva, Geneva 1211, Switzerland.ORCID 0000-0002-0247-2007
Manuel A FrieseInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0001-6380-2420
Universität Hamburg · DEUniversity Hospital of Geneva · CHInstitute of Biomedical Sciences, Academia Sinica · TWFraunhofer Institute for Translational Medicine and Pharmacology · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation causes neuronal injury in multiple sclerosis (MS) and other neurological diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but knowledge about their contribution to neuronal protection or damage during inflammation is limited. Here, we constructed a regulatory miRNA-mRNA network of inflamed motor neurons by leveraging cell type-specific miRNA and mRNA sequencing of mice undergoing experimental autoimmune encephalomyelitis (EAE). We found robust induction of miR-92a in inflamed spinal cord neurons and identified cytoplasmic polyadenylation element-binding protein 3 (

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMicroRNAsMultiple SclerosisAnimalsHumansInflammationMiceMice, Inbred C57BLNeuroinflammatory DiseasesNeuronsRNA-Binding ProteinsRNA, MessengerCPEB3 protein, humanMicroRNAsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID38000031
PMCPMC10672163
OpenAlexW4388966688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.