Evidence map›Paper›PMID 37999830›Full record

ReviewCurrent neurology and neuroscience reports2023

Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia.

Amritha Harikumar, Kseniya P Solovyeva, Maria Misiura, Armin Iraji, Sergey M Plis, Godfrey D Pearlson, Jessica A Turner, Vince D Calhoun

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Disrupted cortical organization in schizophrenia based on functional connectivity gradients.European archives of psychiatry and clinical neuroscience · 2026
    Article
  8. Review
  9. Article
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  11. Schizophrenia.Nature reviews. Disease primers · 2025
    Review
  12. Review
  13. Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amritha HarikumarThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Kseniya P SolovyevaThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Maria MisiuraThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Armin IrajiThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Sergey M PlisThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Godfrey D PearlsonDepartments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Jessica A TurnerThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Vince D CalhounThe Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA. vcalhoun@gsu.edu.

Funding

Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
CRCNS: Multimodal Dynamic Causal Learning for NeuroimagingR01MH129047 · NIMH · GEORGIA STATE UNIVERSITY · PI PLIS, SERGEY · 2021 to 2024
$1.3M
NIBIB NIH HHS R01 EB006841NIMH NIH HHS R01 MH129047
6 · The paper itself

Abstract

purpose of reviewOver the last decade, evidence suggests that a combination of behavioral and neuroimaging findings can help illuminate changes in functional dysconnectivity in schizophrenia. We review the recent connectivity literature considering several vital models, considering connectivity findings, and relationships with clinical symptoms. We reviewed resting state fMRI studies from 2017 to 2023. We summarized the role of two sets of brain networks (cerebello-thalamo-cortical (CTCC) and the triple network set) across three hypothesized models of schizophrenia etiology (neurodevelopmental, vulnerability-stress, and neurotransmitter hypotheses). RECENT

findingsThe neurotransmitter and neurodevelopmental models best explained CTCC-subcortical dysfunction, which was consistently connected to symptom severity and motor symptoms. Triple network dysconnectivity was linked to deficits in executive functioning, and the salience network (SN)-default mode network dysconnectivity was tied to disordered thought and attentional deficits. This paper links behavioral symptoms of schizophrenia (symptom severity, motor, executive functioning, and attentional deficits) to various hypothesized mechanisms.

Indexed as

SchizophreniaBrainBrain MappingHumansMagnetic Resonance ImagingNeural PathwaysNeurotransmitter AgentsNeurotransmitter AgentsBrain networksDisconnectivityDysconnectivityFunctional connectivitySchizophrenia

Identifiers

PMID37999830
PMCPMC11126894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.