Evidence map›Paper›PMID 37999825›Full record

ReviewCurrent oncology reports2023

Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives.

Thien Huong N Huynh, Davis R Kuruvilla, Matthew D Nester, Guston Zervoudakis, G Douglas Letson, David M Joyce, Odion T Binitie, Alexander L Lazarides

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thien Huong N HuynhUniversity of South Florida Health Morsani College of Medicine, Tampa, FL, USA.
Davis R KuruvillaUniversity of South Florida Health Morsani College of Medicine, Tampa, FL, USA.
Matthew D NesterUniversity of South Florida Health Morsani College of Medicine, Tampa, FL, USA.
Guston ZervoudakisDepartment of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
G Douglas LetsonDepartment of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
David M JoyceDepartment of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
Odion T BinitieDepartment of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
Alexander L LazaridesDepartment of Sarcoma, Moffitt Cancer Center, Tampa, FL, USA. alexander.lazarides@moffitt.org.
Moffitt Cancer Center · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review summarizes current findings regarding limb amputation within the context of cancer, especially in osteosarcomas and other bony malignancies. We seek to answer the question of how amputation is utilized in the contemporary management of cancer as well as explore current advances in limb-sparing techniques. RECENT

findingsThe latest research on amputation has been sparse given its extensive history and application. However, new research has shown that rotationplasty, osseointegration, targeted muscle reinnervation (TMR), and regenerative peripheral nerve interfaces (RPNI) can provide patients with better functional outcomes than traditional amputation. While limb-sparing surgeries are the mainstay for managing musculoskeletal malignancies, limb amputation is useful as a palliative technique or as a primary treatment modality for more complex cancers. Currently, rotationplasty and osseointegration have been valuable limb-sparing techniques with osseointegration continuing to develop in recent years. TMR and RPNI have also been of interest in the modern management of patients requiring full or partial amputations, allowing for better control over myoelectric prostheses.

Indexed as

Artificial LimbsBone NeoplasmsOsteosarcomaAmputation, SurgicalHumansAmputationOsseointegrationOsteosarcomaRegenerative peripheral nerve interfacesRotationplastyTargeted muscle reinnervation

Identifiers

PMID37999825
OpenAlexW4388975067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.