Evidence map›Paper›PMID 37999813›Full record

ArticleMikrochimica acta2023

A label-free electrochemical biosensor based on PBA-Au-MXene QD for miR-122 detection in serum samples.

Sara Ranjbari, Behnaz Hatamluyi, Seyed Hamid Aghaee-Bakhtiari, Majid Rezayi, Reza Arefinia

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sara RanjbariChemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Behnaz HatamluyiAntimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Hamid Aghaee-BakhtiariDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid RezayiCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza ArefiniaChemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran. arefinia@um.ac.ir.
Ferdowsi University of Mashhad · IRMashhad University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IR

Funding

Ferdowsi University of Mashhad 55634Shahid Beheshti University 29339
6 · The paper itself

Abstract

A poly(n-butyl acrylate)-gold-MXene quantum dots (PBA-Au-MXene QD) nanocomposite-based biosensor is presented that is modified by unique antisense single-stranded DNA (ssDNA) and uses the electrochemical detection methods of DPV, CV, and EIS to early detect miR-122 as a breast cancer biomarker in real clinical samples. This fabrication method is based on advanced nanotechnology, at which a poly(n-butyl acrylate) (PBA) as a non-conductive polymer transforms into a conductive composite by incorporating Au-MXene QD. This biosensor had a limit of detection (LOD) of 0.8 zM and a linear range from 0.001 aM to 1000 nM, making it capable of detecting the low concentrations of miR-122 in patient samples. Moreover, it allows approximately 100% sensitivity and 100% specificity for miR-122 without extraction. The synthesis and detection characteristics were evaluated by different complementary tests such as AFM, FTIR, TEM, and FESEM. This new biosensor can have a high potential in clinical applications to detect breast cancer early and hence improve patient outcomes.

Indexed as

Biosensing TechniquesBreast NeoplasmsMicroRNAsAcrylatesBiomarkers, TumorFemaleHumansNitritesPolymersTransition ElementsAcrylatesBiomarkers, TumorMicroRNAsMIRN122 microRNA, humanMXeneNitritesPolymerspoly(n-butyl acrylate)Transition ElementsBiosensorBreast cancerCancer diagnosisCyclic voltammetryDifferential pulse voltammetryEISmiR-122PBA-Au-MXene QD

Identifiers

PMID37999813
OpenAlexW4388975852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.