SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024
Clinical significance of cement leakage in kyphoplasty and vertebroplasty: a systematic review.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models for subsequent vertebral fractures after percutaneous vertebroplasty or kyphoplasty: a systematic review and critical appraisal.BMC musculoskeletal disorders · 2026Pooled it
- Complications of vertebral augmentation in metastatic spinal fractures: a systematic review of multiple study designs.Journal of bone oncology · 2026Review
- Clinical Outcomes of Percutaneous Vertebroplasty and Conservative Management in Patients With Osteoporotic Vertebral Compression Fractures.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Outcomes following structural allograft-chain impaction kyphoplasty.North American Spine Society journal · 2026Article
- Sphereplasty with 3D porous titanium microspheres for thoracolumbar vertebral compression fractures: analysis of clinical efficacy and safety profile of a novel technique.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Per-Vertebra Prediction of Future Osteoporotic Fractures from Routine Computed Tomography Using a Two-Stage Machine Learning Framework.Medicina (Kaunas, Lithuania) · 2026Article
- Development and validation of a nomogram model for predicting bone cement leakage during vertebroplasty.BMC surgery · 2026Article
- Cement leakage into adjacent vertebra during percutaneous vertebroplasty: "Gild the Lily" or "Kill two birds with one stone"?International journal of surgery (London, England) · 2026Article
- Bone cement displacement after percutaneous vertebroplasty for a three-column fracture: a case report.BMC surgery · 2026Article
- Pulmonary embolism and cement leakage in cement-augmented spinal instrumentation: incidence, associated factors, and clinical impact.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Effect of dominant cement distribution zone on pain relief after unipedicular percutaneous vertebroplasty.Frontiers in surgery · 2026Article
- A comparative study on percutaneous vertebroplasty for osteoporotic vertebral compression fractures under day surgery and inpatient management models.Frontiers in surgery · 2026Article
- Efficacy of Percutaneous Vertebroplasty Assisted by a Curved Cement Delivery Guide for Osteoporotic Vertebral Compression Fractures in the Elderly.Clinical interventions in aging · 2026Article
- Asymptomatic Multiple Bilateral Segmental Pulmonary Embolisms Caused by Cement After Multilevel Vertebroplasty: A Case Report and Literature Review.Case reports in surgery · 2026Article
- Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis.European journal of medical research · 2025Article
- Genant grade-based stratification in percutaneous curved kyphoplasty: Superior early analgesic efficacy and cement distribution characteristics in moderate to severe osteoporotic vertebral compression fractures.Neurosurgical review · 2025Article
- Development and validation of a nomogram prediction model for osteoporotic vertebral compression re-fracture after percutaneous kyphoplasty based on lumbar local fat parameters.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Case Report: Bone cement leakage in the right heart: a rare case of misinterpreted echocardiographic findings.Frontiers in surgery · 2025Article
- Efficacy of percutaneous cement discoplasty combined with PVP for the treatment of stage III Kümmell disease with an adjacent disc vacuum sign.Frontiers in surgery · 2025Article
- Global Research Trends and Hotspots on Percutaneous Kyphoplasty and Osteoporotic Vertebral Body Compression Fractures: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporotic vertebral compression fractures affect a large number of elderly people and cause significant issues with pain and mobility. Percutaneous vertebroplasty (PVP) and kyphoplasty (PKP) are employed to treat those who remain symptomatic, with comparable clinical outcomes. Although PVP is faster and less expensive, concerns around cement-leakage complications make PKP perceptively safer.
methodsBy means of systematic review, we sought to ascertain whether PVP did carry a higher risk of cement-leakage and associated symptomatic complications (neural compromise, pulmonary embolism and need for emergency decompression surgery).
resultsOur search of 138 articles returned six studies after shortlisting and manual review: three randomised-controlled trials, and three retrospective comparative studies which met our criteria and directly compared cement-leakage rates and complications between the two treatments. 532 PVPs and 493 PKPs recorded 213 (39.3%) and 143 (28.9%) leaks, respectively (p < 0.0005). Of these, no leaks resulted in any of the aforementioned leak-related complications. No meta-analysis was performed due to heterogeneity of the data.
conclusionsWe therefore concluded that whilst PVP does result in more cement leaks, this does not appear to be clinically significant. Further studies would add weight to this conclusion, and cost-effectiveness should be assessed to restore confidence in PVP. LEVEL OF EVIDENCE: Level III Evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.