Evidence map›Paper›PMID 37999745›Full record

ArticlePsychopharmacology2024

Electroconvulsive therapy improves hematological inflammatory markers in bipolar disorder.

Eman Ali, Ahmed Embaby, Shaymaa M Arafa, Ahmed Kamal Elbana, Mohamed Ghazala, Doaa Ibrahim

Abstract read
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In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Eman AliPsychiatry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed EmbabyClinical Hematology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Al-Sharika, Zagazig, 44519, Egypt. Dr.embaby@yahoo.com.ORCID http://orcid.org/0000-0002-9078-0463
Shaymaa M ArafaPsychiatry Department, Faculty of Medicine, Al Azhar University for Girls, Cairo, Egypt.
Ahmed Kamal ElbanaAnatomy Department, Faculty of Medicine, Al Azhar University for Men, Cairo, Egypt.
Mohamed GhazalaClinical Sciences Department, Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia.
Doaa IbrahimPsychiatry Department, Faculty of Medicine, Al Azhar University for Girls, Cairo, Egypt.
Al-Azhar University · EGZagazig University · EGSulaiman Al Rajhi Colleges · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune dysfunction and inflammation participate in the pathophysiology of bipolar disorder (BD). Abnormal levels of inflammatory markers, namely, red cell distribution width (RDW) and platelet distribution width (PDW), were detected in BD. Electroconvulsive therapy (ECT) for various mental disorders including BD was linked to changes in these inflammatory mediators. Hence, we aimed to assess the impact of ECT on PDW and RDW in patients with BD.

methodsSeventy-two patients aged ≥ 16 were enrolled in the current prospective cohort study over 6 months, diagnosed as BD based on DSM-IV and indicated for ECT and complete blood count (CBC) drawn pre-ECT and after four ECT sessions.

resultsBy the end of the ECT sessions, we noticed a significant elevation in PDW with lowering in RDW levels. However, no significant differences were detected before and after ECT regarding platelet (PLTs) count, mean platelet volume (MPV), and Plateletcrit (PCT).

conclusionECT seems to improve the CBC-derived inflammatory markers (RDW and PDW) subsequently, improving the underlying inflammatory process in BD without disturbing PLT homeostasis which support its anti-inflammatory role in BD.

Indexed as

Bipolar DisorderElectroconvulsive TherapyBlood PlateletsHumansMean Platelet VolumeProspective StudiesBipolar disorderElectroconvulsive therapyMean platelet volumePlatelet distribution widthPlatelet parametersRed cell distribution width

Identifiers

PMID37999745
OpenAlexW4388975558

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.