Evidence map›Paper›PMID 37999529›Full record

ArticleToxins2023

Association between Dental Scores and Saliva Uremic Toxins.

Claire Rigothier, Sylvain Catros, Antoine Bénard, Johan Samot, Olivier Quintin, Christian Combe, Islam Larabi, Ziad Massy, Jean-Claude Alvarez

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02114281 (Oral and Dental Health Status in Patients Suffering From Chronic Kidney Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02114281 nacompletednot on this map

Oral and Dental Health Status in Patients Suffering From Chronic Kidney Disease

TypeinterventionalSponsorUniversity Hospital, BordeauxRan2014 to 2017Enrolled88ConditionsChronic Kidney DiseaseArmsCare, Not care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Claire RigothierService de Néphrologie-Transplantation-Dialyse-Aphérèses, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-5569-5562
Sylvain CatrosINSERM, Bio-Ingénierie Tissulaire (BioTis), UMR 1026, Université de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-3419-3467
Antoine BénardClinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France.
Johan SamotDépartement de Chirurgie Orale, CHU de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-6087-2375
Olivier QuintinClinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-9354-8897
Christian CombeService de Néphrologie-Transplantation-Dialyse-Aphérèses, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-0360-573X
Islam LarabiService de Pharmacologie-Toxicologie, Hôpital Raymond Poincaré, AP-HP, 92380 Garchesy, France.ORCID 0000-0002-9015-5342
Ziad MassyCentre for Research in Epidemiology and Population Health, Inserm UMRS 1018, Clinical Epidemiology Team, Université Paris Saclay (Versailles Saint Quentin-en-Yvelines), 78035 Villejuif, France.
Jean-Claude AlvarezService de Pharmacologie-Toxicologie, Hôpital Raymond Poincaré, AP-HP, 92380 Garchesy, France.ORCID 0000-0001-5344-9475
Centre Hospitalier Universitaire de Bordeaux · FRInserm · FRUniversité de Bordeaux · FR

Funding

CHU de Bordeaux CHUBX 2013/11
6 · The paper itself

Abstract

Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.

Indexed as

Renal Insufficiency, ChronicToxins, BiologicalUremiaChromatography, LiquidHippuratesHumansIndicanMethylaminesProspective StudiesSalivaTandem Mass SpectrometryUremic ToxinsHippurateshippuric acidIndicanMethylaminesToxins, BiologicaltrimethyloxamineUremic Toxinschronic kidney diseasedental healthsalivauremic toxins

Identifiers

PMID37999529
PMCPMC10674306
OpenAlexW4388830822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.