Evidence map›Paper›PMID 37999466›Full record

ArticleVeterinary sciences2023

Unveiling Oxidative Stress-Induced Genotoxicity and Its Alleviation through Selenium and Vitamin E Therapy in Naturally Infected Cattle with Lumpy Skin Disease.

Waqas Ahmad, Adeel Sattar, Mehmood Ahmad, Muhammad Waqar Aziz, Asif Iqbal, Muhammad Yasin Tipu, Rana Muhammad Zahid Mushtaq, Naeem Rasool, Hafiz Saleet Ahmed, Muhammad Ahmad

Open access · goldAbstract read
In one paragraph

Article in Veterinary sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Waqas AhmadDepartment of Pathology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0001-8485-9557
Adeel SattarDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0000-0003-1124-4046
Mehmood AhmadDepartment of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Muhammad Waqar AzizInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0009-0003-3447-5629
Asif IqbalDepartment of Parasitology, Riphah International University, Lahore 54000, Pakistan.ORCID 0000-0003-1127-1941
Muhammad Yasin TipuDepartment of Pathology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Rana Muhammad Zahid MushtaqDivision of Infection Medicine, College of Medicine, The University of Edinburgh, Edinburgh EH16 4SB, UK.
Naeem RasoolDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Hafiz Saleet AhmedDepartment of Livestock Management, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Muhammad AhmadDepartment of Pathology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Islamia University of Bahawalpur · PKUniversity of Veterinary and Animal Sciences · PKRiphah International University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lumpy skin disease (LSD) is a contagious infection of cattle caused by a virus of the Poxviridae family, genus Capripoxvirus. In Pakistan, recent outbreaks have resulted in significant nationwide mortality and economic losses. A 20-day prospective cohort study was performed on sixty infected cattle with the aim to evaluate LSD-induced oxidative stress's genotoxic role and to determine the ameliorative effect of antioxidant therapy using principal component analysis (PCA) and a multivariable ordinal logistic regression model. LSDV was identified from scab samples and nodular lesions using RPO30-specific gene primers. The infected cattle were divided into control and treated groups. The animals were observed initially and finally on day 20 to evaluate the homeostatic, oxidative, and genotoxic changes. The animals in the treated group were administered a combination of selenium (Se) and vitamin E at the standard dose rate for five consecutive days. A substantial (

Indexed as

comet assaygenotoxicityLumpy skin diseaseoxidative stressPakistanseleniumtocopherol

Identifiers

PMID37999466
PMCPMC10675407
OpenAlexW4388451745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.