Evidence map›Paper›PMID 37999249›Full record

ArticleMetabolites2023

Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability.

Emilie J Benson, Danielle I Aronowitz, Rodrigo M Forti, Alec Lafontant, Nicolina R Ranieri, Jonathan P Starr, Richard W Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann and 11 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  9. Pathlength-selective, interferometric diffuse correlation spectroscopy.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Emilie J BensonDepartment of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7633-489X
Danielle I AronowitzDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rodrigo M FortiDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-8978-2525
Alec LafontantDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-3669-0114
Nicolina R RanieriDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-6823-8328
Jonathan P StarrDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Richard W MelchiorDepartment of Perfusion Services, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Alistair LewisDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5968-4169
Jharna JahnaviDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jake BreimannDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Bohyun YunDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Gerard H LaurentDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jennifer M LynchDivision of Cardiothoracic Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Brian R WhiteDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
J William GaynorDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-7955-5604
Daniel J LichtDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Arjun G YodhDepartment of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Constantine D MavroudisDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Wesley B BakerDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-3025-6061
Tiffany S KoDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-5113-0310
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeR01HL141386 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KILBAUGH, TODD JUSTEN · 2019 to 2023
$4.4M
Diffuse Optics for Pediatric Hydrocephalus ManagementR01NS113945 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI BAKER, WESLEY · 2020 to 2024
$1.9M
Optical Functional Neuroimaging of Acute and Chronic HypoxiaK08NS117897 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WHITE, BRIAN RICHARD · 2020 to 2024
$843k
Functional Diffuse Optical Measurements of Psychomotor Function in Neonates with Hypoplastic Left Heart Syndrome (HLHS)F31HD085731 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI KO, TIFFANY S · 2016 to 2019
$133k
NHLBI NIH HHS R01 HL141386NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NICHD NIH HHS F31 HD085731NIH HHS K08-NS117897, R01-NS060653, R01-NS113945, T32-HL007915, R01-HL141386, P41-EB015893, F31-HD085731NINDS NIH HHS K08 NS117897NINDS NIH HHS R01 NS060653NINDS NIH HHS R01 NS113945
6 · The paper itself

Abstract

Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally unknown. To elucidate this physiology, we used diffuse correlation spectroscopy and frequency-domain diffuse optical spectroscopy to continuously measure CBF, oxygen extraction fraction (OEF), and oxygen metabolism (CMRO

Indexed as

cardiopulmonary bypasscerebral hemodynamicsdiffuse opticshemoconcentrationmild hypothermia

Identifiers

PMID37999249
PMCPMC10672802
OpenAlexW4388723544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.