Evidence map›Paper›PMID 37999242›Full record

ArticleMetabolites2023

Sphingolipids in Childhood Asthma and Obesity (SOAP Study): A Protocol of a Cross-Sectional Study.

Belavendra Antonisamy, Harshita Shailesh, Yahya Hani, Lina Hayati M Ahmed, Safa Noor, Salma Yahya Ahmed, Mohamed Alfaki, Abidan Muhayimana, Shana Sunny Jacob, Saroja Kotegar Balayya and 11 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. [Research Advancements in Gastric Capacity Intervention for Childhood and Adolescent Obesity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Association of Childhood Asthma with the Concept of Exposomics: A Short Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Belavendra AntonisamyDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0003-3582-2410
Harshita ShaileshDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0003-2055-4644
Yahya HaniDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Lina Hayati M AhmedDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Safa NoorDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Salma Yahya AhmedDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Mohamed AlfakiDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Abidan MuhayimanaDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Shana Sunny JacobAnalytical Chemistry Core, Advanced Diagnostic Core Facilities, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Saroja Kotegar BalayyaAnalytical Chemistry Core, Advanced Diagnostic Core Facilities, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Oleksandr SoloviovClinical Genomics Laboratory, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Li LiuClinical Genomics Laboratory, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Lisa Sara MathewClinical Genomics Laboratory, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0003-3177-2233
Kun WangClinical Genomics Laboratory, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Sara TomeiOmics Core, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0001-5334-9140
Alia Al MassihOmics Core, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Rebecca MathewOmics Core, Integrated Genomics Services, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Mohammed Yousuf KarimDepartment of Pathology, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Manjunath RamanjaneyaQatar Metabolic Institute, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Stefan WorgallDepartment of Pediatrics, Weill Cornell Medicine, New York, NY 10021, USA.
Ibrahim A JanahiDepartment of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0002-6531-7362
Cornell University · USHamad Medical Corporation · QAQatar University · QAWeill Cornell Medical College in Qatar · QA

Funding

Qatar National Research Fund NPRP-X-090-3-037
6 · The paper itself

Abstract

Asthma and obesity are two of the most common chronic conditions in children and adolescents. There is increasing evidence that sphingolipid metabolism is altered in childhood asthma and is linked to airway hyperreactivity. Dysregulated sphingolipid metabolism is also reported in obesity. However, the functional link between sphingolipid metabolism, asthma, and obesity is not completely understood. This paper describes the protocol of an ongoing study on sphingolipids that aims to examine the pathophysiology of sphingolipids in childhood asthma and obesity. In addition, this study aims to explore the novel biomarkers through a comprehensive multi-omics approach including genomics, genome-wide DNA methylation, RNA-Seq, microRNA (miRNA) profiling, lipidomics, metabolomics, and cytokine profiling. This is a cross-sectional study aiming to recruit 440 children from different groups: children with asthma and normal weight (

Indexed as

asthmachildrenobesityserine palmitoyltransferasesphingolipids

Identifiers

PMID37999242
PMCPMC10673587
OpenAlexW4388634222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.