Evidence map›Paper›PMID 37999222›Full record

ArticleMetabolites2023

An Engineered Plant Metabolic Pathway Results in High Yields of Hydroxytyrosol Due to a Modified Whole-Cell Biocatalysis in Bioreactor.

Glykeria Mermigka, Aikaterini I Vavouraki, Chrysoula Nikolaou, Ioanna Cheiladaki, Michail Vourexakis, Dimitrios Goumas, Filippos Ververidis, Emmanouil Trantas

Abstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Glykeria MermigkaLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.
Aikaterini I VavourakiLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.ORCID 0000-0002-7173-3397
Chrysoula NikolaouLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.
Ioanna CheiladakiLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.
Michail VourexakisLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.
Dimitrios GoumasLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.
Filippos VerveridisLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.ORCID 0000-0002-3104-6103
Emmanouil TrantasLaboratory of Biological and Biotechnological Applications (LBBA), Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University (HMU), GR71410 Heraklion, Greece.ORCID 0000-0001-7536-101X

Funding

European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation Grant code/ Acronym: Τ2ΕΔΚ-01859/ BIOCONTROL
6 · The paper itself

Abstract

Hydroxytyrosol (HT) is a phenolic substance primarily present in olive leaves and olive oil. Numerous studies have shown its advantages for human health, making HT a potentially active natural component with significant added value. Determining strategies for its low-cost manufacturing by metabolic engineering in microbial factories is hence still of interest. The objective of our study was to assess and improve HT production in a one-liter bioreactor utilizing genetically modified

Indexed as

aldehyde reductasearomatic acetaldehyde synthasebioreactorHPLC-MS/MShydroxytyrosolmetabolic engineeringmicrobial biotechnologysynthetic biologytyrosinasewhole cell biocatalysis

Identifiers

PMID37999222
PMCPMC10672836

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.