ArticleGels (Basel, Switzerland)2023
Alginate-Gelatin Hydrogel Scaffolds; An Optimization of Post-Printing Treatment for Enhanced Degradation and Swelling Behavior.
Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- After the Nozzle: Post-Printing Maturation, Failure Modes, and Use-Point Assessment of Cell-Laden Extrusion-Bioprinted Hydrogel Constructs.Gels (Basel, Switzerland) · 2026Review
- κ-Carrageenan-Based Hydrogels Support Viability and Odontogenic Differentiation of Stem Cells From the Apical Papilla.International dental journal · 2026Article
- Bioinspired 3D Printing of Lignocellulose-Based Multimaterial Composites for Extracellular Matrix-Mimicking Architectures.Biomimetics (Basel, Switzerland) · 2026Review
- 3D-Bioprinted Multifunctional Nanocomposite Scaffolds for Alveolar Bone-Periodontal Ligament-Root Cementum Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Cryogenic Foaming of Silk Fibroin Composite for Scaffolds in Bone and Periodontal Regeneration.Journal of functional biomaterials · 2026Article
- Microglia encapsulation in nanozyme-loaded hydrogels: response to oxidative stress and inflammation.Nanomedicine (London, England) · 2026Article
- Hydrogel platforms for engineered live biotherapeutics: materials, microbial integration and clinical potential.RSC pharmaceutics · 2026Review
- Interpenetrating gelatin/sodium alginate hydrogel with controlled PRP lysate delivery for accelerating diabetic wound healing with reduced scarring.RSC advances · 2026Article
- Gelatin-sodium alginate hydrogel infused withBiochemistry and biophysics reports · 2025Article
- Hydrogels in the Immune Context: In Vivo Applications for Modulating Immune Responses in Cancer Therapy.Gels (Basel, Switzerland) · 2025Review
- High-Precision Multi-Axis Robotic Printing: Optimized Workflow for Complex Tissue Creation.Bioengineering (Basel, Switzerland) · 2025Article
- Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials.Gels (Basel, Switzerland) · 2025Article
- Developing Bioengineered 3D-Printed Composite Scaffolds with Antimicrobial Potential for Bone Tissue Regeneration.Journal of functional biomaterials · 2025Article
- Effects of Polyhydroxybutyrate-co-hydroxyvalerate Microparticle Loading on Rheology, Microstructure, and Processability of Hydrogel-Based Inks for Bioprinted and Moulded Scaffolds.Gels (Basel, Switzerland) · 2025Article
- Three-Dimensional Printing of Hydrogel as Skin Substitute and Comparative Evaluation of Melanin Production.Bioengineering (Basel, Switzerland) · 2025Article
- Development of Personalised Immediate-Release Gel-Based Formulations Using Semi-Solid Extrusion.Gels (Basel, Switzerland) · 2024Article
- Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation.Polymers · 2024Review
- Flax fibre reinforced alginate poloxamer hydrogel: assessment of mechanical and 4D printing potential.Soft matter · 2024Article
- Recent Advances in Scaffolds for Guided Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024Review
- Evaluating cells metabolic activity of bioinks for bioprinting: the role of cell-laden hydrogels and 3D printing on cell survival.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The generation of 3D structures comprises three interlinked phases: material development, the printing process, and post-printing treatment. Numerous factors control all three phases, making the optimization of the entire process a challenging task. Until now, the state of the art has mainly focused on optimizing material processability and calibration of the printing process. However, after the successful Direct Ink Writing (DIW) of a hydrogel scaffold, the post-printing stage holds equal importance, as this allows for the treatment of the structure to ensure the preservation of its structural integrity for a duration that is sufficient to enable successful cell attachment and proliferation before undergoing degradation. Despite this stage's pivotal role, there is a lack of extensive literature covering its optimization. By studying the crosslinking factors and leveling the post-treatment settings of alginate-gelatin hydrogel, this study proposes a method to enhance scaffolds' degradation without compromising the targeted swelling behavior. It introduces an experimental design implementing the Response Surface Methodology (RSM) Design of Experiments (DoE), which elucidated the key parameters influencing scaffold degradation and swelling, and established an alginate ratio of 8% and being immersed for 15 min in 0.248 M CaCl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.