ArticleGels (Basel, Switzerland)2023
Evaluation of the Effect of Honey-Containing Chitosan/Hyaluronic Acid Hydrogels on Wound Healing.
Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Redox-Regulating Propolis- and Honey-Containing Hydrogels in Osteoarthritis.Antioxidants (Basel, Switzerland) · 2026Review
- Efficient Chitosan-Ferulic Acid Hydrogel Formation at Neutral pH by a Two-Domain Bacterial Laccase: Mechanistic and Functional Study.Polymers · 2026Article
- Combination of Manuka Honey and Chitosan-Based Biomaterial for the Treatment of Dehisced Wound: Case Report.Life (Basel, Switzerland) · 2026Article
- A novel composite hyaluronic acid/chitosan/polyvinyl alcohol ternary hydrogel scaffold for periodontal regeneration: an experimental study.BMC oral health · 2026Article
- Article
- Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing.Pharmaceutics · 2026Review
- Article
- Preparation of polysaccharide composite films using cyclodextrin-conjugated chitosan for sustained release of hydrophobic drugs.RSC advances · 2025Article
- Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation.Bioactive materials · 2025Article
- Kelulut Honey-Incorporated Hybrid Gelatin-PVA Hydrogel for Wound Healing: Fabrication and In Vitro Characterization.Polymers · 2025Article
- Editorial for the Special Issue "Feature Papers in Chemistry and Physics of Biological Gels".Gels (Basel, Switzerland) · 2025Article
- Toward Natural Wound Healing Therapy: Honey andPharmaceutics · 2025Article
- Supercritical Fluid-Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment.Advanced healthcare materials · 2025Article
- A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications.Gels (Basel, Switzerland) · 2025Review
- Sticky Science: Using Complex Coacervate Adhesives for Biomedical Applications.Advanced healthcare materials · 2025Review
- Honey-Based Sodium Alginate-Polyvinyl Alcohol Hydrogel Containing Green-Synthesized Chitosan-Zinc Oxide Nanoparticles for Wound Healing.Bioinorganic chemistry and applications · 2025Article
- Trends in the Treatment of Chronic Wounds.Current medicinal chemistry · 2025Review
- [Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Less Pain with Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis Compared to Placebo: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Pharmaceuticals (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 3D polymeric network structure of hydrogels imitates the extracellular matrix, thereby facilitating cell growth and differentiation. In the current study, chitosan/hyaluronic acid/honey coacervate hydrogels were produced without any chemicals or crosslinking agents and investigated for their wound-healing abilities. Chitosan/hyaluronic acid/honey hydrogels were characterized by FTIR, SEM, and rheology analysis. Moreover, their water content, water uptake capacities, and porosity were investigated. In FT-IR spectra, it was discovered that the characteristic band placement of chitosan with hyaluronic acid changed upon interacting with honey. The porosity of the honey-containing hydrogels (12%) decreased compared to those without honey (17%). Additionally, the water-uptake capacity of honey-containing hydrogels slightly decreased. Also, it was observed that hydrogels' viscosity increased with the increased hyaluronic acid amount and decreased with the amount of honey. The adhesion and proliferation of fibroblast cells on the surface of hydrogel formulations were highest in honey-containing hydrogels (144%). In in vivo studies, wound healing was accelerated by honey addition. It has been demonstrated for the first time that honey-loaded chitosan-hyaluronic acid hydrogels, prepared without the use of toxic covalent crosslinkers, have potential for use in wound healing applications.
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