Evidence map›Paper›PMID 37998821›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Role of Relebactam in the Antibiotic Resistance Acquisition in

Maria Paz Ventero, Jose M Haro-Moreno, Carmen Molina-Pardines, Antonia Sánchez-Bautista, Celia García-Rivera, Vicente Boix, Esperanza Merino, Mario López-Pérez, Juan Carlos Rodríguez

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. mSphere · 2026
    Article
  2. The relationship between virulence and drug resistance genes inFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maria Paz VenteroMicrobiology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0003-1979-0949
Jose M Haro-MorenoEvolutionary Genomics Group, División de Microbiología, Universidad Miguel Hernández, Apartado 18, 03550 San Juan de Alicante, Spain.
Carmen Molina-PardinesMicrobiology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
Antonia Sánchez-BautistaMicrobiology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
Celia García-RiveraMicrobiology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0003-1701-2916
Vicente BoixInfectious Diseases Unit, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
Esperanza MerinoInfectious Diseases Unit, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0003-3854-4874
Mario López-PérezEvolutionary Genomics Group, División de Microbiología, Universidad Miguel Hernández, Apartado 18, 03550 San Juan de Alicante, Spain.
Juan Carlos RodríguezMicrobiology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0001-8007-5739
Instituto de investigación sanitaria y biomédica de AlicanteUniversitat de Miguel Hernández d'Elx · ES

Funding

Instituto de investigación sanitaria y biomédica de Alicante 2021-0377Merk & CO, INC IISP 57739Ministerio de Ciencia e Innovación PTA2021-020215-I
6 · The paper itself

Abstract

background

objectiveDevelop an in vitro model, using clinical isolates of

methodsThe antibiotics resistance was studied by microdilution assays and e-test, and the genotypic study was performed by NGS.

resultsThe isolates acquired resistance to imipenem in an average of 6 days, and to imipenem/relebactam in 12 days ( DISCUSSION: The addition of relebactam delays the generation of resistance to imipenem and limits the cross-resistance to other beta-lactams. The clinical relevance of this phenomenon, which has the limitation that it has been performed in vitro, should be evaluated by stewardship programs in clinical practice, as it could be useful in controlling multi-drug resistance in

Indexed as

antibiotic resistancePseudomonas aeruginosarelebactam

Identifiers

PMID37998821
PMCPMC10668777
OpenAlexW4388636686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.