Evidence map›Paper›PMID 37998759›Full record

ArticleCurrent issues in molecular biology2023

Hippocampal Upregulation of Complement Component C3 in Response to Lipopolysaccharide Stimuli in a Model of Fragile-X Syndrome.

Danielle Santana-Coelho, Joaquin N Lugo

Open access · goldAbstract read
In one paragraph

Article in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Danielle Santana-CoelhoDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.ORCID 0000-0003-3784-2036
Joaquin N LugoDepartment of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA.ORCID 0000-0001-6874-8718
Baylor University · US

Funding

Signaling Mechanisms Underlying Epilepsy and Autism CormorbidityR15NS088776 · NINDS · BAYLOR UNIVERSITY · PI JOAQUIN N LUGO · 2015 to 2026
$1.8M
NIH HHS R15NS088776NINDS NIH HHS R15 NS088776
6 · The paper itself

Abstract

The complement system is part of the innate immune system and has been shown to be altered in autism spectrum disorder (ASD). Fragile-X syndrome (FXS) is the main genetic cause of ASD and studies suggest a dysregulation in the immune system in patients with the disorder. To assess if an animal model of FXS presents with altered complement signaling, we treated male

Indexed as

autismautism spectrum disordercomplementcytokinesFXSneuroinflammation

Identifiers

PMID37998759
PMCPMC10669955
OpenAlexW4388829936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.