Evidence map›Paper›PMID 37998716›Full record

ReviewCurrent issues in molecular biology2023

Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers.

Ane Larrea, Ane Elexpe, Eguzkiñe Díez-Martín, María Torrecilla, Egoitz Astigarraga, Gabriel Barreda-Gómez

Open access · goldAbstract readReview
In one paragraph

Review in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ane LarreaResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain.ORCID 0000-0002-9231-2233
Ane ElexpeResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain.
Eguzkiñe Díez-MartínResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain.ORCID 0000-0002-7151-1639
María TorrecillaDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0003-0830-9988
Egoitz AstigarragaResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain.ORCID 0000-0002-0338-5554
Gabriel Barreda-GómezResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, Spain.ORCID 0000-0002-8330-1567
University of the Basque Country · ES

Funding

Basque Government through funding from the BIKAINTEK program 006-B2/2021 and 48-AF-W2-2019-00007The University of the Basque Country through the PIF Industrial program PIFIND21/02
6 · The paper itself

Abstract

Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients' quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years.

Indexed as

biomarkersneuroinflammationstroketherapytraumatic injury

Identifiers

PMID37998716
PMCPMC10670324
OpenAlexW4388267217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.