Evidence map›Paper›PMID 37998588›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Cancer Diagnosis through Contour Visualization of Gene Expression Leveraging Deep Learning Techniques.

Vinoth Kumar Venkatesan, Karthick Raghunath Kuppusamy Murugesan, Kaladevi Amarakundhi Chandrasekaran, Mahesh Thyluru Ramakrishna, Surbhi Bhatia Khan, Ahlam Almusharraf, Abdullah Albuali

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Vinoth Kumar VenkatesanSchool of Computer Science Engineering and Information Systems (SCORE), Vellore Institute of Technology, Vellore 632014, India.ORCID 0000-0003-1070-3212
Karthick Raghunath Kuppusamy MurugesanDepartment of Computer Science and Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be University), Bangalore 562112, India.ORCID 0000-0002-6948-5240
Kaladevi Amarakundhi ChandrasekaranDepartment of Computer Science and Engineering, Sona College of Technology, Salem 636005, India.
Mahesh Thyluru RamakrishnaDepartment of Computer Science and Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be University), Bangalore 562112, India.
Surbhi Bhatia KhanDepartment of Data Science, School of Science Engineering and Environment, University of Salford, Manchester M5 4WT, UK.ORCID 0000-0003-3097-6568
Ahlam AlmusharrafDepartment of Business Administration, College of Business and Administration, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-3206-547X
Abdullah AlbualiDepartment of Computer Science, School of Computer Science and Information Technology, King Faisal University, Hofuf 11671, Saudi Arabia.
Jain University · INKing Faisal University · SAPrincess Nourah bint Abdulrahman University · SAUniversity of Religions and Denominations · IRVellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prompt diagnostics and appropriate cancer therapy necessitate the use of gene expression databases. The integration of analytical methods can enhance detection precision by capturing intricate patterns and subtle connections in the data. This study proposes a diagnostic-integrated approach combining Empirical Bayes Harmonization (EBS), Jensen-Shannon Divergence (JSD), deep learning, and contour mathematics for cancer detection using gene expression data. EBS preprocesses the gene expression data, while JSD measures the distributional differences between cancerous and non-cancerous samples, providing invaluable insights into gene expression patterns. Deep learning (DL) models are employed for automatic deep feature extraction and to discern complex patterns from the data. Contour mathematics is applied to visualize decision boundaries and regions in the high-dimensional feature space. JSD imparts significant information to the deep learning model, directing it to concentrate on pertinent features associated with cancerous samples. Contour visualization elucidates the model's decision-making process, bolstering interpretability. The amalgamation of JSD, deep learning, and contour mathematics in gene expression dataset analysis diagnostics presents a promising pathway for precise cancer detection. This method taps into the prowess of deep learning for feature extraction while employing JSD to pinpoint distributional differences and contour mathematics for visual elucidation. The outcomes underscore its potential as a formidable instrument for cancer detection, furnishing crucial insights for timely diagnostics and tailor-made treatment strategies.

Indexed as

accuracycancerclassificationcomputationcontourdetectiondiagnosislossprecisionrecallvisualization

Identifiers

PMID37998588
PMCPMC10670706
OpenAlexW4388694493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.