Evidence map›Paper›PMID 37998502›Full record

ArticleJournal of cardiovascular development and disease2023

A Comparative Assessment of Myocardial Work Performance during Spontaneous Rhythm, His Bundle Pacing, and Left Bundle Branch Area Pacing: Insights from the EMPATHY Study.

Giorgia Azzolini, Nicola Bianchi, Francesco Vitali, Michele Malagù, Cristina Balla, Martina De Raffele, Matteo Bertini

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Article
  3. Mid- to long-term mechanical performance of left bundle branch area pacing: a comprehensive echocardiographic comparison of capture modalities.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giorgia AzzoliniCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.
Nicola BianchiCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-4643-1629
Francesco VitaliCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-0667-7616
Michele MalagùCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-1972-9665
Cristina BallaCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0003-2110-8961
Martina De RaffeleCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0003-4193-0418
Matteo BertiniCardiology Unit, Sant'Anna University Hospital, Department of Translational Medicine, University of Ferrara, Via A. Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-5285-7140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysiological pacing has gained significant interest due to its potential to achieve optimal hemodynamic response. This study aimed to assess left ventricular performance in terms of electrical parameters, specifically QRS duration and mechanical performance, evaluated as myocardial work. We compared His Bundle Pacing (HBP) and Left Bundle Branch Area Pacing (LBBAP) to evaluate their effects.

methodsTwenty-four patients with class I or IIa indications for pacing were enrolled in this study, with twelve patients undergoing HBP implantation and another twelve undergoing LBBAP implantation. A comprehensive analysis of myocardial work was conducted.

resultsOur findings indicate that there were no major differences in terms of spontaneous and HBP activation in myocardial work, except for global wasted work (217 mmHg% vs. 283 mmHg%;

conclusionsBoth pacing modalities provide physiological ventricular activation without significant differences when compared to each other. Moreover, there were no significant differences in QRS duration between HBP and LBBAP. However, LBBAP demonstrated advantages in terms of feasibility, as it achieved better lead electrical parameters compared to HBP (threshold@0.4 ms 0.6 V vs. 1 V;

Indexed as

conduction system pacinghis bundle pacingleft bundle branch area pacingphysiological pacing

Identifiers

PMID37998502
PMCPMC10672524

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.