Evidence map›Paper›PMID 37998501›Full record

ArticleJournal of cardiovascular development and disease2023

Dynamic Perfusion Computed Tomography for the Assessment of Concomitant Coronary Artery Disease in Patients with a History of Percutaneous Transluminal Angioplasty for Chronic Limb-Threatening Ischemia-A Pilot Study.

Ferenc T Nagy, Dorottya Olajos, Borbála Vattay, Sarolta Borzsák, Melinda Boussoussou, Mónika Deák, Milán Vecsey-Nagy, Barbara Sipos, Ádám L Jermendy, Gábor G Tóth and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Ferenc T NagyDivision of Invasive Cardiology, Department of Internal Medicine, University of Szeged, 6725 Szeged, Hungary.
Dorottya OlajosDivision of Invasive Cardiology, Department of Internal Medicine, University of Szeged, 6725 Szeged, Hungary.
Borbála VattayHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Sarolta BorzsákHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.ORCID 0000-0003-1578-3354
Melinda BoussoussouHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Mónika DeákBács-Kiskun County Hospital, 6725 Kecskemét, Hungary.
Milán Vecsey-NagyHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.ORCID 0000-0001-9306-289X
Barbara SiposHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Ádám L JermendyHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Gábor G TóthGraz University Heart Center Graz, Medical University of Graz, 8036 Graz, Austria.
Balázs NemesHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Tamás Szili-TörökDivision of Invasive Cardiology, Department of Internal Medicine, University of Szeged, 6725 Szeged, Hungary.
Zoltán RuzsaDivision of Invasive Cardiology, Department of Internal Medicine, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0002-2474-5723
Bálint SzilveszterHeart and Vascular Center, Semmelweis University, Határőr Str. 18, 1122 Budapest, Hungary.
Semmelweis University · HUUniversity of Szeged · HUBács-Kiskun Megyei Kórház · HUMedical University of Graz · AT

Funding

European Union RRF-2.3.1-21-2022-00003
6 · The paper itself

Abstract

backgroundChronic limb-threatening ischemia (CLTI) is associated with high rates of long-term cardiovascular mortality. Exercise stress testing to detect obstructive coronary artery disease (CAD) can be difficult in this subset of patients due to inability to undergo exercise testing, presence of balanced ischemia and severe coronary artery calcification (CAC).

aimTo test the feasibility of regadenoson stress dynamic perfusion computed tomography (DPCT) in CLTI patients.

methodsBetween 2018 and 2023, coronary computed tomography angiography (CTA) and, in the case of a calcium score higher than 400, DPCT, were performed in 25 CLTI patients with a history of endovascular revascularization.

resultsOf the 25 patients, 19 had a calcium score higher than 400, requiring DPCT image acquisition. Obstructive CAD could be ruled out in 10 of the 25 patients. Of the 15 CTA/DPCT+ patients, 13 proceeded to coronary angiography (CAG). Revascularization was necessary in all 13 patients. In these 13 patients, vessel-based sensitivity and specificity of coronary CTA/DPCT as compared to invasive evaluation was 75%, respectively. At follow-up (27 ± 21 months) there was no statistically significant difference in all-cause mortality between CTA/DPCT- positive and -negative patients (

conclusionsDespite a high prevalence of severe CAC, coronary CTA complemented by DPCT may be a feasible method to detect obstructive and functionally significant CAD in CLTI patients.

Indexed as

chronic limb-threatening ischemia (CLTI)regadenoson stress dynamic perfusion computed tomography (DPCT)

Identifiers

PMID37998501
PMCPMC10671941
OpenAlexW4387937777

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.