Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors at 5 institutions in 3 countries.
Grace Mercedes FrekeGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Tiago MartinsGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Rosalind Jane DaviesGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Tina BeyerInstitute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0002-6302-8997
Marian SedaGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0002-5634-3585
Emma PeskettGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Naila HaqGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0003-1887-5449
Avishek PrasaiLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Georg OttoGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0002-3929-948X
Jeshmi Jeyabalan SrikaranGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0002-0195-8478
Victor HernandezLife Sciences Department, CHMLS, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK.ORCID 0000-0002-4424-1848
Gaurav D DiwanBioQuant, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
Robert B RussellBioQuant, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
Marius UeffingInstitute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0003-2209-2113
Martina HuranovaLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.ORCID 0000-0002-4403-1146
Karsten BoldtInstitute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany.ORCID 0000-0002-2693-689X
Philip L BealesGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0002-9164-9782
Dagan JenkinsGreat Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
University College London · GBUniversity of Tübingen · DECzech Academy of Sciences, Institute of Molecular Genetics · CZHeidelberg University · DEBrunel University of London · GB
Funding
Medical Research Council MR/L009978/1Wellcome TrustWellcome Trust 210585/Z/18/Z
6 · The paper itself
Abstract
Bardet-Biedl syndrome (BBS) is an archetypal ciliopathy caused by dysfunction of primary cilia. BBS affects multiple tissues, including the kidney, eye and hypothalamic satiety response. Understanding pan-tissue mechanisms of pathogenesis versus those which are tissue-specific, as well as gauging their associated inter-individual variation owing to genetic background and stochastic processes, is of paramount importance in syndromology. The BBSome is a membrane-trafficking and intraflagellar transport (IFT) adaptor protein complex formed by eight BBS proteins, including BBS1, which is the most commonly mutated gene in BBS. To investigate disease pathogenesis, we generated a series of clonal renal collecting duct IMCD3 cell lines carrying defined biallelic nonsense or frameshift mutations in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
De-Suppression of Mesenchymal Cell Identities and Variable Phenotypic Outcomes Associated with Knockout of · full record | OpenQuestion