Evidence map›Paper›PMID 37998385›Full record

ArticleCells2023

Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.

Sentiljana Gumeni, Maria Lamprou, Zoi Evangelakou, Maria S Manola, Ioannis P Trougakos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sentiljana GumeniDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.ORCID 0000-0003-0033-2008
Maria LamprouDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.ORCID 0000-0002-9808-5350
Zoi EvangelakouDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.
Maria S ManolaDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.ORCID 0000-0002-6975-2812
Ioannis P TrougakosDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15784 Athens, Greece.ORCID 0000-0002-6179-2772
National and Kapodistrian University of Athens · GR

Funding

European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RE-SEARCH - CREATE - INNOVATE Τ2ΕDΚ-01410/MIS 5095061
6 · The paper itself

Abstract

The modulation of insulin/insulin-like growth factor signaling (IIS) is associated with altered nutritional and metabolic states. The

Indexed as

Diabetes Mellitus, Type 2Drosophila ProteinsHyperglycemiaSomatomedinsAnimalsDrosophilaDrosophila melanogasterInsulinInsulin-Like Growth Factor Binding ProteinsNF-E2-Related Factor 2Nitrosourea CompoundsRepressor Proteinscnc protein, DrosophilaDrosophila ProteinsImpL2 protein, DrosophilaInsulinInsulin-Like Growth Factor Binding ProteinsNF-E2-Related Factor 2Nitrosourea CompoundsN,N'-bis((2-chloroethyl)nitrosocarbamoyl)cystamineRepressor ProteinsSomatomedinscncCImpL2insulin/insulin-like growth factorsmetforminNrf2

Identifiers

PMID37998385
PMCPMC10670064
OpenAlexW4388795332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.