Evidence map›Paper›PMID 37998373›Full record

ArticleCells2023

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.

Jiawen Xiang, Anthony J Pompetti, Adam P Faranda, Yan Wang, Samuel G Novo, David Wan-Cheng Li, Melinda K Duncan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Transcriptional Readthrough atbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jiawen XiangDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Anthony J PompettiDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Adam P FarandaDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-6993-8361
Yan WangDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Samuel G NovoDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0002-6400-0013
David Wan-Cheng LiThe State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510230, China.
Melinda K DuncanDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0003-1570-322X
University of Delaware · USSun Yat-sen University · CN

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
The Influence of Capsule Composition on Lens BiologyR01EY015279 · NEI · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2004 to 2025
$7.8M
The mechanisms underlying posterior capsular opacificationR01EY028597 · NEI · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2018 to 2021
$1.5M
Acquisition of a Zeiss LSM710 Confocal MicroscopeS10RR027273 · NCRR · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2010 to 2010
$494k
NCRR NIH HHS S10 RR027273NEI NIH HHS EY015279-18NEI NIH HHS EY028597-01NEI NIH HHS R01 EY015279NEI NIH HHS R01 EY028597NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P20GM104316NIGMS NIH HHS P20 GM139760NIGMS NIH HHS S10RR027273-01
6 · The paper itself

Abstract

The late embryonic mouse lens requires the transcription factor ATF4 for its survival although the underlying mechanisms were unknown. Here, RNAseq analysis revealed that E16.5

Indexed as

Lens, CrystallineAmino AcidsAnimalsCell DifferentiationGene Expression RegulationMiceMice, KnockoutTranscription FactorsAmino AcidsTranscription Factorsamino acidsATF4CREB-2glutathionelens developmenttransporter

Identifiers

PMID37998373
PMCPMC10670291
OpenAlexW4388735077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.