ReviewCells2023
Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment.
Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06909344 (Effectiveness and Safety of 577-nm Diode Laser in the Treatment of Non -Inflammatory Acne), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness and Safety of 577-nm Diode Laser in the Treatment of Non -Inflammatory Acne
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Effects of isotretinoin on bone dynamics in the craniomaxillofacial region: a systematic review of preclinical evidence.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Alterations in the lipid profile in acne vulgaris patients: A meta-analysis.The Journal of international medical research · 2026Pooled it
- Individualizing isotretinoin dosing in acne: comparable 24-week efficacy and better tolerability at lower daily doses.Frontiers in medicine · 2026Pooled it
- Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin.The Australasian journal of dermatology · 2025Pooled it
- Craniofacial development: genetics, signaling pathways, teratogenic mechanisms, and clinal significance.Molecular biomedicine · 2026Review
- Decoding Sebaceous Gland Biology Through Experimental Models: Progress, Limitations, and Future Directions.Cells · 2026Review
- From pixels to pimples.JID innovations : skin science from molecules to population health · 2026Article
- Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.The Journal of clinical investigation · 2026Article
- Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris.JCI insight · 2026Article
- Advances in Nanotechnology-Based Topical Delivery Systems for Skincare Applications.Pharmaceutics · 2026Review
- Multidimensional assessment of acne vulgaris: links between psychiatric symptoms, disordered eating, and dermatologic severity.Frontiers in medicine · 2026Article
- Targeting macrophage polarization: mechanisms and potential of mesenchymal stromal/stem cells therapy in acne treatment- a narrative review.Frontiers in immunology · 2026Review
- Lipid-Based Nanocarriers as a Promising Delivery System in the Management of Acne.Current pharmaceutical design · 2026Review
- Isotretinoin-Associated Serum Creatinine Elevation During Acne Treatment: A Case Report.Clinical, cosmetic and investigational dermatology · 2026Article
- Exposome involvement in the development of acne vulgaris.Frontiers in immunology · 2026Review
- Isotretinoin-Associated Myopathy With Normal Creatine Kinase (CK) Levels: EMG-Based Diagnosis at Low Dose-A Case Report.Clinical case reports · 2025Article
- Real-World Safety of Oral Isotretinoin in Patients During Sunny Months: Retrospective Cohort Study.Dermatology practical & conceptual · 2025Article
- Isotretinoin Treatment for Acne Vulgaris: A Five-Year Retrospective Analysis of Clinical and Biochemical Adverse Effects.Journal of clinical medicine · 2025Article
- Review
- The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases.Cells · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic target of rapamycin complex 1 (mTORC1). A Western diet (hyperglycemic carbohydrates and milk/dairy products) also co-stimulates AKT/mTORC1 signaling. The AKT-mediated phosphorylation of nuclear FoxO1 and FoxO3 results in their extrusion into the cytoplasm, a critical switch which enhances the transactivation of lipogenic and proinflammatory transcription factors, including androgen receptor (AR), sterol regulatory element-binding transcription factor 1 (SREBF1), peroxisome proliferator-activated receptor γ (PPARγ) and signal transducer and activator of transcription 3 (STAT3), but reduces the FoxO1-dependent expression of GATA binding protein 6 (GATA6), the key transcription factor for infundibular keratinocyte homeostasis. The AKT-mediated phosphorylation of the p53-binding protein MDM2 promotes the degradation of p53. In contrast, isotretinoin enhances the expression of p53, FoxO1 and FoxO3 in the sebaceous glands of acne patients. The overexpression of these proapoptotic transcription factors explains isotretinoin's desirable sebum-suppressive effect via the induction of sebocyte apoptosis and the depletion of BLIMP1(+) sebocyte progenitor cells; it also explains its adverse effects, including teratogenicity (neural crest cell apoptosis), a reduced ovarian reserve (granulosa cell apoptosis), the risk of depression (the apoptosis of hypothalamic neurons), VLDL hyperlipidemia, intracranial hypertension and dry skin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.