ArticleThe American journal of pathology1986
Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury.
Article in The American journal of pathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 111 citations in OpenAlex.
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- Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.The American journal of pathology · 2017Article
- Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.Fibrogenesis & tissue repair · 2013Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Switching-on of serotonergic calcium signaling in activated hepatic stellate cells.World journal of gastroenterology · 2011Article
- Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species.BMC cell biology · 2009Article
- Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis.Inflammation · 2008Article
- Promotion of colon cancer metastases in rat liver by fish oil diet is not due to reduced stroma formation.Clinical & experimental metastasis · 2000Article
- Dynamic changes of type I,III and IV collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis.World journal of gastroenterology · 1999Article
- Expression of the Na+/Ca2+ exchanger emerges in hepatic stellate cells after activation in association with liver fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The hepatic stellate (Ito) cell: its role in human liver disease.Virchows Archiv : an international journal of pathology · 1997Review
- Spongiotic pericytoma: a benign neoplasm deriving from the perisinusoidal (Ito) cells in rat liver.The American journal of pathology · 1995Article
- The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.The American journal of pathology · 1995Article
- Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver.Virchows Archiv : an international journal of pathology · 1994Article
- Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis.Virchows Archiv. A, Pathological anatomy and histopathology · 1993Article
- Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis.International journal of experimental pathology · 1992Article
- Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity.The Biochemical journal · 1992Article
- Alcoholic liver disease. Parenchyma to stroma relationship in fibrosis and cirrhosis as revealed by three-dimensional reconstruction and immunohistochemistry.The American journal of pathology · 1992Article
- Carcinoma-associated perisinusoidal laminin may signal tumour cell metastasis to the liver.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistochemical investigations were carried out on the properties of the cells and extracellular matrix (ECM) in focal hepatic injuries. A liquid nitrogen-cooled syringe needle was thrust into the rat liver. Necrotic areas became permeated with plasma within 24-hour period. Areas became strongly positive for fibronectin and were infiltrated with inflammatory cells positive for lysozyme. By the third day, Ito cells were proliferated in the peripheral portions of the damaged areas. These Ito cells showed enhanced immunostaining for desmin and actin but were negative for lysozyme. Interstitial fibers which were immunochemically positive for Types I and IV collagens, laminin, and fibronectin, began to increase from Day 3. They appeared on the rim of the hepatocytes adjacent to the damaged areas and extended into the injured regions with the Ito cells. An increase in basal laminas associated with capillaries and bile ducts also increased with a 1-day delay. The damaged areas were replaced by granulation tissue by Day 5. A rapid diminution then occurred in the granulation tissue, and normal hepatic tissue was restored in 7-10 days. These observations demonstrate that ECM changed in a sequential manner and then finally disappeared from the damaged site within 10 days. Although various cells, including parenchymal cells, macrophages, endothelial cells, and cholangiolar cells contributed to the healing of the damaged area, Ito cells, which exhibit unique phenotypic changes, presumably had a major role in the process.
Indexed as
Identifiers
3799820PMC1888465W776815294What OpenQuestion holds
Registered trials
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