Evidence map›Paper›PMID 37998130›Full record

ArticleBiosensors2023

A Polyamidoamine-Based Electrochemical Aptasensor for Sensitive Detection of Ochratoxin A.

Xiujin Chen, Dong Gao, Jiaqi Chen, Xueqing Wang, Chifang Peng, Hongli Gao, Yao Wang, Zhaozhou Li, Huawei Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiujin ChenHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Dong GaoHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Jiaqi ChenHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Xueqing WangHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Chifang PengSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-0589-0455
Hongli GaoHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Yao WangHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Zhaozhou LiHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Huawei NiuHanan International Joint Laboratory of Food Green Processing and Quality Safety Control, National Demonstration Center for Experimental Food Processing and Safety Education, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Henan University of Science and Technology · CNJiangnan University · CN

Funding

Chifang Peng 31871879Yao Wang 31702218Zhaozhou Li 31701694
6 · The paper itself

Abstract

Sensitive detection of ochratoxin A (OTA) is significant and essential because OTA may pose risks to human and animal health. Here, we developed an electrochemical aptasensor for OTA analysis using polyamidoamine (PAMAM) dendrimers as a signal amplifier. As a carrier, PAMAM has numerous primary amino groups that can be coupled with thiolated complementary strand DNA (cDNA), allowing it to recognize aptamers bound to the surface of horseradish peroxidase (HRP)-modified gold nanoparticles (AuNPs), thereby improving the sensitivity of the aptasensor. When monitoring the positive samples, OTA was captured by the aptamer fixed on the HRP-conjugated AuNP surface by specific recognition, after which the formed OTA-aptamer conjugates were detached from the electrode surface, ultimately decreasing the electrochemical signal monitored by differential pulse voltammetry. The novel aptasensor achieved a broad linear detection range from 5 to 10

Indexed as

Aptamers, NucleotideBiosensing TechniquesMetal NanoparticlesOchratoxinsDNA, ComplementaryElectrochemical TechniquesGoldHumansLimit of DetectionPolyaminesAptamers, NucleotideDNA, ComplementaryGoldochratoxin AOchratoxinsPoly(amidoamine)PolyaminesAuNPselectrochemical aptasensorgraphene oxideOchratoxin APAMAM

Identifiers

PMID37998130
PMCPMC10669513
OpenAlexW4387957233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.