Evidence map›Paper›PMID 37997993›Full record

ArticleBiology2023

NF-kB Regulation and the Chaperone System Mediate Restorative Effects of the Probiotic

Letizia Paladino, Francesca Rappa, Rosario Barone, Filippo Macaluso, Francesco Paolo Zummo, Sabrina David, Marta Anna Szychlinska, Fabio Bucchieri, Everly Conway de Macario, Alberto J L Macario and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
  2. Foods (Basel, Switzerland) · 2025
    Article
  3. Nutrients · 2025
    Article
  4. TargetingNutrients · 2025
    Review
  5. Article
  6. Foods (Basel, Switzerland) · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Letizia PaladinoDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-8037-7761
Francesca RappaDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-6610-5268
Rosario BaroneDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-6491-3640
Filippo MacalusoDepartment of SMART Engineering Solutions & Technologies, eCampus University, 22060 Novedrate, Italy.
Francesco Paolo ZummoDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-9872-8574
Sabrina DavidDepartment Surgical, Oncological and Oral Sciences, School of Medicine, University of Palermo, 90133 Palermo, Italy.
Marta Anna SzychlinskaFaculty of Medicine and Surgery, UKE-Kore University of Enna, Cittadella Universitaria, 94100 Enna, Italy.ORCID 0000-0001-5281-1516
Fabio BucchieriDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.
Everly Conway de MacarioEuro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy.
Alberto J L MacarioEuro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy.ORCID 0000-0002-6181-2876
Francesco CappelloDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-9288-1148
Antonella Marino GammazzaDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-1683-3803
University of Palermo · ITIstituto Euro Mediterraneo di Scienza e Tecnologia · ITUniversity of Maryland, Baltimore · USIstituto di Farmacologia Traslazionale · ITUniversità degli Studi di Enna Kore · ITUniversità degli Studi eCampus · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics are live microorganisms that yield health benefits when consumed, generally by improving or restoring the intestinal flora (microbiota) as part of the muco-microbiotic layer of the bowel. In this work, mice were fed with ethanol alone or in combination with the probiotic

Indexed as

chaperone systemethanolgut-brain axisgut microbiotaheat shock proteinsLactobacillus fermentum

Identifiers

PMID37997993
PMCPMC10669058
OpenAlexW4388226783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.