Evidence map›Paper›PMID 37997762›Full record

ArticleClinical cardiology2024

Application of AMR in evaluating microvascular dysfunction after ST-elevation myocardial infarction.

Hao Wang, Qi Wu, Lang Yang, Long Chen, Wen-Zhong Liu, Jun Guo, Jing-Song Xu

Open access · goldAbstract read
In one paragraph

Article in Clinical cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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  9. Single-view angiographic microcirculatory resistance index after primary PCI: the EARLY-MYO-AMR study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hao WangDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.ORCID http://orcid.org/0009-0009-4069-1911
Qi WuThe First Affiliated Hospital of Nanchang University, Nanchang, China.
Lang YangDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Long ChenShanghai Pulse Medical Technology Inc., Shanghai, China.
Wen-Zhong LiuDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jun GuoDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jing-Song XuDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA guidewire-free angiography-derived microcirculatory resistance (AMR) derived from Quantitative flow ratio (QFR) exhibits good diagnostic accuracy for assessing coronary microvascular dysfunction (CMD), but there are no relevant studies supporting the specific application of AMR in patients with ST-elevation myocardial infarction (STEMI). The study aims to evaluate CMD in patients with STEMI using the AMR index.

methodsThis study included patients with STEMI who underwent percutaneous coronary intervention (PCI) from June 1, 2020 to September 28, 2021. All patients were divided into two groups: the CMD (n = 215) and non-CMD (n = 291) groups. After matching, there were 382 patients in both groups.1-year follow-up major adverse cardiac events (MACEs) were evaluated.

resultsAfter matching, the primary endpoint was achieved in 41 patients (10.7%), with 27 and 14 patients in the CMD and non-CMD groups, respectively (HR 1.954 [95% CI 1.025-3.726]; 14.1% versus 7.3%, p = .042). Subgroup analysis revealed that 18 patients (4.7%) were readmitted for heart failure, with 15 and 3 in the CMD and non-CMD groups, respectively (HR 5.082 [95% CI 1.471-17.554]; 7.9% versus 1.6%, p = .010). Post-PCI AMR ≥ 250 was significantly associated with a higher risk of the primary endpoint and was its independent predictor (HR 2.265 [95% CI 1.136-4.515], p = .020).

conclusionThe retrospective use of AMR with a cutoff value of ≥250 after PCI in patients with STEMI can predict a significant difference in the 1-year MACE rates when compared with a propensity score-matched group with normal AMR.

Indexed as

Myocardial IschemiaPercutaneous Coronary InterventionST Elevation Myocardial InfarctionCoronary AngiographyHumansMicrocirculationRetrospective StudiesTreatment Outcomeangiography-derived microcirculatory resistance (AMR)coronary microvascular dysfunction (CMD)major adverse cardiovascular events (MACE)quantitative flow ratio (QFR)ST-elevation myocardial infarction (STEMI)

Identifiers

PMID37997762
PMCPMC10823552
OpenAlexW4388982412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.