Observational studyThe journal of nutrition, health & aging2023
The Impact of Frailty Status on Pulmonary Function and Mortality in Older Patients with Chronic Obstructive Pulmonary Disease.
Observational study in The journal of nutrition, health & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Frailty and longitudinal pulmonary function trajectories in lung transplant recipients.Respiratory research · 2026Article
- Dynamic frailty trajectories and risk of chronic obstructive pulmonary disease: a large-scale prospective cohort study.BMC pulmonary medicine · 2026Article
- Change of frailty index and anthropometric indices in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Causal effects of physical activity and frailty on pneumothorax risk: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Article
- Sarcopenia as a Stronger Predictor for All-Cause Mortality Than Osteoporosis in a Medical Center in Central Taiwan.Clinical interventions in aging · 2025Article
- Sarcopenia as a Stronger Predictor for All-Cause Mortality than Osteoporosis in a Medical Center in Central Taiwan [Response to Letter].Clinical interventions in aging · 2025Article
- The relationship between respiratory symptoms and frailty: findings from observational and Mendelian randomization analyses.Aging clinical and experimental research · 2024Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe aimed to evaluate the effect of frailty on lung function and disease outcomes in older adults with chronic obstructive pulmonary disease (COPD).
designRetrospective observational cohort. SETTING AND
participantsAt baseline, comprehensive geriatric assessment and pulmonary function tests were extracted from the case management care system of the geriatric department of a tertiary medical center. MEASUREMENTS: Frailty was assessed by the modified Rockwood frailty index. Kaplan-Meier survival and Cox proportional hazard analyses were used to analyze the primary outcome. Both the Friedman test and generalized estimating equations were used to evaluate the rate of decline in lung function.
resultsAmong 151 enrolled older patients, comprising 69 non-COPD and 82 COPD subjects, the mean age was 80.9±8.3 years. After a median follow-up of 2.87 years, the serial forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC), and forced expiratory flow at 25-75% of FVC (FEF25-75%) showed significantly different slope changes between older COPD patients with and without frailty. The mortality hazard ratio (HR) was 2.53 for COPD without frailty and 3.62 for COPD with frailty, versus those without COPD. Among COPD patients, the factors most strongly associated with mortality were timed up-and-go, activities of daily living (ADLs), instrumental ADLs, FEV1/FVC, and serum HCO3-. After adjustment for potential confounders, ADLs and FEV1/FVC remained independent mortality predictors.
conclusionAmong older patients with COPD, frailty was common and associated with pulmonary function decline, and mortality risk was higher in frail than in non-frail subjects.
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