Evidence map›Paper›PMID 37997640›Full record

ArticleOrganic letters2023

Progress toward the Total Synthesis of Jogyamycin Using a Tandem Ichikawa/Winstein Rearrangement.

Kate A Nicastri, Nels C Gerstner, Jennifer M Schomaker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kate A NicastriDepartment of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0003-4960-0608
Nels C GerstnerDepartment of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Jennifer M SchomakerDepartment of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1329-950X
University of Wisconsin–Madison · US

Funding

Synthetic approaches to complex amines that inhibit protein synthesis by impacting the ribosomeR01GM111412 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCHOMAKER, JENNIFER MARIE · 2014 to 2022
$2.4M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
Enantioselective Synthesis of Jogyamycin and Development of a Predictive Binding Model Enabled by Analog SynthesisF31GM122300 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GERSTNER, NELS · 2017 to 2018
$57k
NMR SPECTROMETERS10RR008389 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI VEDEJS, EDWIN · 1993 to 1993
–
NCRR NIH HHS S10 RR008389NIGMS NIH HHS F31 GM122300NIGMS NIH HHS R01 GM111412NIH HHS S10 OD020022
6 · The paper itself

Abstract

Jogyamycin is a densely functionalized aminocyclopentitol that displays potent antiprotozoal activity. Herein, we report a route toward this natural product that utilizes an unprecedented transformation involving a tandem Ichikawa-Winstein rearrangement to install the C-1/C-2 diamine core. Attempts to further functionalize the C-3/C-4 alkene en route to jogyamycin are also discussed.

Indexed as

AlkenesBiological ProductsPactamycinStereoisomerismAlkenesBiological ProductsjogyamycinPactamycin

Identifiers

PMID37997640
PMCPMC10789149
OpenAlexW4388524730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.