Evidence map›Paper›PMID 37997592›Full record

ArticleJournal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America2023

Transfer learning of individualized treatment rules from experimental to real-world data.

Lili Wu, Shu Yang

Open access · greenAbstract read
In one paragraph

Article in Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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  7. Causal Inference Methods for Combining Randomized Trials and Observational Studies: A Review.Statistical science : a review journal of the Institute of Mathematical Statistics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lili WuDepartment of Statistics, North Carolina State University.
Shu YangDepartment of Statistics, North Carolina State University.
North Carolina State University · US

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
Transforming Clinical Trials for Elderly and Rare Cancers through Intelligent and Robust Information BorrowingR01AG066883 · NIA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaofei Wang, Shu Yang · 2020 to 2026
$2.0M
Spatial Causal Inference for Wildland Fire Smoke Effects on Air Pollution and HealthR01ES031651 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI REICH, BRIAN J., YANG, SHU · 2020 to 2024
$1.2M
NCI NIH HHS P01 CA142538NIA NIH HHS R01 AG066883NIEHS NIH HHS R01 ES031651
6 · The paper itself

Abstract

Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard approach to estimating the ITRs is randomized experiments, where subjects are randomized to different treatment groups and the confounding bias is minimized to the extent possible. However, experimental studies are limited in external validity because of their selection restrictions, and therefore the underlying study population is not representative of the target real-world population. Conventional learning methods of optimal interpretable ITRs for a target population based only on experimental data are biased. On the other hand, real-world data (RWD) are becoming popular and provide a representative sample of the target population. To learn the generalizable optimal interpretable ITRs, we propose an integrative transfer learning method based on weighting schemes to calibrate the covariate distribution of the experiment to that of the RWD. Theoretically, we establish the risk consistency for the proposed ITR estimator. Empirically, we evaluate the finite-sample performance of the transfer learner through simulations and apply it to a real data application of a job training program.

Indexed as

Augmented inverse probability weightingCalibration weightingClassification errorCovariate shiftCross-validationTransportability

Identifiers

PMID37997592
PMCPMC10664843
OpenAlexW4308326639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.