ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Synthetic Collagen Hydrogels through Symmetric Self-Assembly of Small Peptides.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Functionalized bio-patches for intra-abdominal applications.iScience · 2026Review
- Influence of linker design on the stability, folding, and assembly of tethered collagen-mimetic peptides.RSC chemical biology · 2026Article
- Real-time visualization of collagen assembly uncovers metastable properties in hierarchical organization.Nature communications · 2026Article
- Engineering Design of Artificial Phase-Separating Proteins.Biotechnology journal · 2026Review
- Programmable Steric Control of Collagen Peptide-to-Fiber Assembly.Journal of the American Chemical Society · 2026Article
- Supramolecular Assembly of Collagen-Mimetic Peptide D-Periodic Fibrils and Nanoassemblies.Biomacromolecules · 2026Article
- Hydrogels Formed by the Self-Assembly of Collagen-Mimetic Peptides With a Constrained Backbone Structure.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- A Collagen Triple Helix without the Superhelical Twist.ACS central science · 2025Article
- Hydrogel-based cardiac patches for myocardial infarction therapy: Recent advances and challenges.Materials today. Bio · 2024Review
- A Collagen Triple Helix without the Super Helical Twist.bioRxiv : the preprint server for biology · 2024Article
- Synthetic Collagen Hydrogels through Symmetric Self-Assembly of Small Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Animal-sourced hydrogels, such as collagen, are widely used as extracellular-matrix (ECM) mimics in tissue engineering but are plagued with problems of reproducibility, immunogenicity, and contamination. Synthetic, chemically defined hydrogels can avoid such issues. Despite the abundance of collagen in the ECM, synthetic collagen hydrogels are extremely rare due to design challenges brought on by the triple-helical structure of collagen. Sticky-ended symmetric self-assembly (SESSA) overcomes these challenges by maximizing interactions between the strands of the triple helix, allowing the assembly of collagen-mimetic peptides (CMPs) into robust synthetic collagen nanofibers. This optimization, however, also minimizes interfiber contacts. In this work, symmetric association states for the SESSA of short CMPs to probe their increased propensity for interfiber association are modelled. It is found that 33-residue CMPs not only self-assemble through sticky ends, but also form hydrogels. These self-assemblies behave with remarkable consistency across multiple scales and present a clear link between their triple-helical architecture and the properties of their hydrogels. The results show that SESSA is an effective and robust design methodology that enables the rational design of synthetic collagen hydrogels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.