Evidence map›Paper›PMID 37996690›Full record

ReviewResults and problems in cell differentiation2024

The Hallmarks of Circulating Hybrid Cells.

Ranish K Patel, Michael Parappilly, Shahrose Rahman, Issac R Schwantes, Marisa Sewell, Nicole R Giske, Riley M Whalen, Naside Gozde Durmus, Melissa H Wong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Implications of Heterotypic Cell Fusion in Cancer.Advances in experimental medicine and biology · 2026
    Review
  3. The authors respond to feedback onFrontiers in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ranish K PatelDepartment of Surgery, Oregon Health & Science University, Portland, OR, USA.
Michael ParappillyDepartment of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
Shahrose Rahman *Department of Surgery, Oregon Health & Science University, Portland, OR, USA.
Issac R Schwantes *Department of Surgery, Oregon Health & Science University, Portland, OR, USA.
Marisa Sewell *Department of Surgery, Oregon Health & Science University, Portland, OR, USA.
Nicole R Giske *Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
Riley M Whalen *Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
Naside Gozde DurmusMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
Melissa H WongDepartment of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA. wongme@ohsu.edu.
Oregon Health & Science University · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While tumor metastases represent the primary driver of cancer-related mortality, our understanding of the mechanisms that underlie metastatic initiation and progression remains incomplete. Recent work identified a novel tumor-macrophage hybrid cell population, generated through the fusion between neoplastic and immune cells. These hybrid cells are detected in primary tumor tissue, peripheral blood, and in metastatic sites. In-depth analyses of hybrid cell biology indicate that they can exploit phenotypic properties of both parental tumor and immune cells, in order to intravasate into circulation, evade the immune response, and seed tumors at distant sites. Thus, it has become increasingly evident that the development and dissemination of tumor-immune hybrid cells play an intricate and fundamental role in the metastatic cascade and can provide invaluable information regarding tumor characteristics and patient prognostication. In this chapter, we review the current understanding of this novel hybrid cell population, the specific hallmarks of cancer that these cells exploit to promote cancer progression and metastasis, and discuss exciting new frontiers that remain to be explored.

Indexed as

NeoplasmsHumansHybrid CellsCellular fusionHallmarks of cancerMacrophageMetastasisNeoplastic-immune cell hybridTumor

Identifiers

PMID37996690
OpenAlexW4388934259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.