ArticleNature biomedical engineering2024
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors.
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Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Bioelectronic interfaces for restoring vision pathways.Materials today. Bio · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Bioinspired Photodetectors: From Nature to Advanced Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Perception, Synaptic Plasticity, and Spiking Neuron Function Enabled by a 2D Ferroelectric NbOBrAdvanced materials (Deerfield Beach, Fla.) · 2026Article
- Next-generation smart ophthalmic biomaterials: From passive response to active interaction and closed-loop control.Bioactive materials · 2026Review
- NIR-Triggered Upconversion-Perovskite Heterostructures for Non-Genetic, Implant-Free Optoelectronic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photovoltaic nanoassembly of nanowire arrays sensitized with colloidal nanocrystals for near-infrared retina photostimulation.Science advances · 2026Article
- Advances in nanomedicine-based retinal drug delivery: mechanisms and translational applications.Journal of nanobiotechnology · 2025Review
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification.Science advances · 2025Article
- Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.Nature reviews bioengineering · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Frontier applications of retinal nanomedicine: progress, challenges and perspectives.Journal of nanobiotechnology · 2025Review
- Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare.Med-X · 2024Article
- Nanotechnology in retinal diseases: From disease diagnosis to therapeutic applications.Biophysics reviews · 2024Review
- Multifunctional human visual pathway-replicated hardware based on 2D materials.Nature communications · 2024Article
- Evolution of Retinal Neuron Fractality When Interfacing with Carbon Nanotube Electrodes.Bioengineering (Basel, Switzerland) · 2024Article
- A silicon diode-based optoelectronic interface for bidirectional neural modulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
36 authors at 7 institutions in 2 countries.
Ruyi Yang *State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.ORCID http://orcid.org/0000-0002-9738-6303
Peng Zhao *State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Liyang Wang *Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Chenli Feng *Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Chen Peng *Laboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai, P. R. China.
Zhexuan WangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Yingying ZhangKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, P. R. China.
Minqian ShenDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Kaiwen ShiState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Shijun WengState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Chunqiong DongDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Fu ZengKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, P. R. China.
Tianyun ZhangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Xingdong ChenState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Shuiyuan WangShanghai Key Lab for Future Computing Hardware and System, School of Microelectronics, Fudan University, Shanghai, P. R. China.ORCID http://orcid.org/0000-0002-1979-7430
Yiheng WangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Yuanyuan LuoState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Qingyuan ChenState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Yuqing ChenState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Chengyong JiangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Shanshan JiaSchool of Computer Science, Institute for Artificial Intelligence, Peking University, Beijing, P.R. China.
Zhaofei YuSchool of Computer Science, Institute for Artificial Intelligence, Peking University, Beijing, P.R. China.
Jian LiuSchool of Computer Science, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-5391-7213
Fei WangDepartment of Hand Surgery, the National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Su JiangDepartment of Hand Surgery, the National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Wendong XuDepartment of Hand Surgery, the National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Liang LiCenter of Brain Sciences, Beijing Institute of Basic Medical Sciences, Beijing, P. R. China.
Gang WangCenter of Brain Sciences, Beijing Institute of Basic Medical Sciences, Beijing, P. R. China.
Xiaofen MoState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Gengfeng ZhengLaboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai, P. R. China.ORCID http://orcid.org/0000-0002-1803-6955
Aihua ChenKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, P. R. China.
Xingtao ZhouState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Chunhui JiangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China. chhjiang70@163.com.ORCID http://orcid.org/0000-0001-7857-9292
Yuanzhi YuanDepartment of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China. yuan.yuanzhi@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-5240-3915
Biao YanState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China. biaoyan@fudan.edu.cn.ORCID http://orcid.org/0000-0003-3252-2965
Jiayi ZhangState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute for Medical and Engineering Innovation, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China. jiayizhang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1575-0723
Eye & ENT Hospital of Fudan University · CNFudan University · CNSun Yat-sen University · CNEast China Normal University · CNChinese Institute for Brain Research · CNPeking University · CNUniversity of Birmingham · GB
Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022ZD0208604Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022ZD0208605National Natural Science Foundation of China (National Science Foundation of China) 820712002
Abstract
Retinal prostheses could restore image-forming vision in conditions of photoreceptor degeneration. However, contrast sensitivity and visual acuity are often insufficient. Here we report the performance, in mice and monkeys with induced photoreceptor degeneration, of subretinally implanted gold-nanoparticle-coated titania nanowire arrays providing a spatial resolution of 77.5 μm and a temporal resolution of 3.92 Hz in ex vivo retinas (as determined by patch-clamp recording of retinal ganglion cells). In blind mice, the arrays allowed for the detection of drifting gratings and flashing objects at light-intensity thresholds of 15.70-18.09 μW mm
Indexed as
BlindnessGoldNanowiresVisual ProsthesisAnimalsEvoked Potentials, VisualFemaleMaleMiceMice, Inbred C57BLPhotoreceptor Cells, VertebrateRetinaRetinal Ganglion CellsTitaniumVision, OcularVisual AcuityGoldTitaniumtitanium dioxide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.