ArticleScientific reports2023
Multi-scale measurement of stiffness in the developing ferret brain.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Measurement of Residual Stress in the Brain.Journal of biomechanical engineering · 2025Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases.Cell death & disease · 2025Review
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Interspecies Comparison of Multilayer Mechanical Properties of Synovium Using Atomic Force Microscopy.Tissue engineering. Part A · 2025Article
- Stress landscape of folding brain serves as a map for axonal pathfinding.Nature communications · 2025Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cortical folding is an important process during brain development, and aberrant folding is linked to disorders such as autism and schizophrenia. Changes in cell numbers, size, and morphology have been proposed to exert forces that control the folding process, but these changes may also influence the mechanical properties of developing brain tissue. Currently, the changes in tissue stiffness during brain folding are unknown. Here, we report stiffness in the developing ferret brain across multiple length scales, emphasizing changes in folding cortical tissue. Using rheometry to measure the bulk properties of brain tissue, we found that overall brain stiffness increases with age over the period of cortical folding. Using atomic force microscopy to target the cortical plate, we found that the occipital cortex increases in stiffness as well as stiffness heterogeneity over the course of development and folding. These findings can help to elucidate the mechanics of the cortical folding process by clarifying the concurrent evolution of tissue properties.
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Registered trials
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