ArticleNature communications2023
A synaptic corollary discharge signal suppresses midbrain visual processing during saccade-like locomotion.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Central coordination of electromotor and locomotor pathways in the weakly electric fish Brevimyrus niger.Research square · 2026Article
- The Effect of 'Hydraulic-Visual' Interaction on the Intensity of Fish Schooling in the Upstream Movement of Juvenile Silver Carp.Ecology and evolution · 2026Article
- Mind's eye: Saccade-related evoked potentials support visual encoding in humans.medRxiv : the preprint server for health sciences · 2025Article
- A detailed quantification of larval zebrafish behavioral repertoire uncovers principles of hunting behavior.iScience · 2025Article
- A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.Nature neuroscience · 2025Article
- Fixational eye movements and edge integration in lightness perception.Vision research · 2025Article
- Revealing the mechanism and function underlying pairwise temporal coupling in collective motion.Nature communications · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In motor control, the brain not only sends motor commands to the periphery, but also generates concurrent internal signals known as corollary discharge (CD) that influence sensory information processing around the time of movement. CD signals are important for identifying sensory input arising from self-motion and to compensate for it, but the underlying mechanisms remain unclear. Using whole-cell patch clamp recordings from neurons in the zebrafish optic tectum, we discovered an inhibitory synaptic signal, temporally locked to spontaneous and visually driven locomotion. This motor-related inhibition was appropriately timed to counteract visually driven excitatory input arising from the fish's own motion, and transiently suppressed tectal spiking activity. High-resolution calcium imaging revealed localized motor-related signals in the tectal neuropil and the upstream torus longitudinalis, suggesting that CD enters the tectum via this pathway. Together, our results show how visual processing is suppressed during self-motion by motor-related phasic inhibition. This may help explain perceptual saccadic suppression observed in many species.
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