Evidence map›Paper›PMID 37996055›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2024

Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma.

Wei Tu, Xinyue Hu, Rongjun Wan, Xiaojun Xiao, Yingchun Shen, Prakhyath Srikaram, Sai Nithin Avvaru, Fuhan Yang, Fengmei Pi, Yufeng Zhou and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
    Review
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  20. Nanoparticles to target asthma.American journal of physiology. Lung cellular and molecular physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Wei TuDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China; The State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Xinyue HuDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Rongjun WanDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xiaojun XiaoThe State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Yingchun ShenDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Prakhyath SrikaramDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Sai Nithin AvvaruDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Fuhan YangDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Fengmei PiExonanoRNA LLC, Columbus, OH 43212, USA.
Yufeng ZhouChildren's Hospital and Institute of Biomedical Sciences, Fudan University, Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, China.
Mei WanDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peisong GaoDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. Electronic address: pgao1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USCentral South University · CNChildren's Hospital of Fudan University · CNShenzhen University · CN

Funding

Environmental Pollutants Potentiate Allergic Inflammation via Functional Axis of Aryl hydrocarbon Receptor, ROS, and CaMKII in AsthmaR01AI141642 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2019 to 2024
$2.9M
Functional role of miR-511-3p in allergic asthma and its underlying mechanismsR01AI153331 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Peisong Gao · 2021 to 2026
$2.7M
Sensitization to Cockroach Allergen: Immune Regulation and Genetic DeterminantsR01ES021739 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2013 to 2017
$1.8M
Mannose Receptor, miR-511-3p, and Macrophage Polarization in AsthmaR21AI121768 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2016 to 2017
$462k
miR-511-3p, a therapeutic target for allergic asthmaR56ES021739 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2018 to 2018
$150k
NIAID NIH HHS R01 AI141642NIAID NIH HHS R01 AI153331NIAID NIH HHS R21 AI121768NIEHS NIH HHS R01 ES021739NIEHS NIH HHS R56 ES021739
6 · The paper itself

Abstract

Our previous studies have shown that miR-511-3p treatment has a beneficial effect in alleviating allergic airway inflammation. Here, we sought to explore its therapeutic potential in animal models and gain a deeper understanding of its therapeutic value for asthma. miR-511-3p knockout mice (miR-511-3p

Indexed as

AsthmaExosomesMicroRNAsAnimalsHumansInflammationMannoseMiceMannoseMicroRNAsMIRN511 microRNA, humanAsthmaComplement C3InflammationMacrophagemiRNA

Identifiers

PMID37996055
PMCPMC10872989
OpenAlexW4388982310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.