Evidence map›Paper›PMID 37996040›Full record

ArticleNeurobiology of disease2024

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.

Emma Jones, Elizabeth Hill, Jacqueline Linehan, Tamsin Nazari, Adam Caulder, Gemma F Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Prion diseases: Lessons from historical outbreaks and potential emerging ones.Protein science : a publication of the Protein Society · 2025
    Review
  9. DNA methylation as a contributor to dysregulation ofbioRxiv : the preprint server for biology · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Emma JonesMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Elizabeth HillMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Jacqueline LinehanMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Tamsin NazariMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Adam CaulderMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire OX11 0RD, UK.
Gemma F CodnerMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire OX11 0RD, UK.
Marie HutchisonMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire OX11 0RD, UK.
Matthew MackenzieMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire OX11 0RD, UK.
Michael FarmerMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Thomas CoyshMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Michael Wiggins De OliveiraMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Huda Al-DoujailyMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Malin SandbergMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Emmanuelle ViréMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Thomas J CunninghamMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Emmanuel A AsanteMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Sebastian BrandnerDivision of Neuropathology and Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
John CollingeMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK.
Simon MeadMedical Research Council Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, London W1W 7FF, UK. Electronic address: s.mead@prion.ucl.ac.uk.
Medical Research Council · GBMary Lyon Centre at MRC Harwell · GBMRC Prion Unit · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is thought to occur when the cellular prion protein (PrP

Indexed as

Creutzfeldt-Jakob SyndromePrion DiseasesPrionsAnimalsBrainGenome-Wide Association StudyHumansMiceMice, TransgenicQa-SNARE ProteinsPrionsQa-SNARE ProteinsCreutzfeldt-Jakob diseaseIncubation periodPrion diseaseSNARESyntaxin-6

Identifiers

PMID37996040
PMCPMC7615600
OpenAlexW4388914324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.