Evidence map›Paper›PMID 37995951›Full record

ArticleExperimental neurology2024

GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPAR

Weitian Lu, Juan Huang, Jerry Flores, Peng Li, Wenna Wang, Shengpeng Liu, John H Zhang, Jiping Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Weitian LuInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Juan HuangInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Jerry FloresDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Peng LiDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Wenna WangDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Shengpeng LiuDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
John H ZhangDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA; Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Jiping TangDepartment of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. Electronic address: jtang@llu.edu.
Loma Linda University · USLoma Linda University Medical Center · US

Funding

Cerebrospinal Fluid Dynamics in Posthemorrhagic Hydrocephalus in NeonatesR01NS103822 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2017 to 2021
$1.7M
Investigating the role of mast cells in neonatal germinal matrix hemorrhageR21NS101284 · NINDS · LOMA LINDA UNIVERSITY · PI TANG, JIPING · 2017 to 2018
$435k
NINDS NIH HHS R01 NS103822NINDS NIH HHS R21 NS101284
6 · The paper itself

Abstract

backgroundActivation of mast cells plays an important role in brain inflammation. CD300a, an inhibitory receptor located on mast cell surfaces, has been reported to reduce the production of pro-inflammatory cytokines and exert protective effects in inflammation-related diseases. Peroxisome proliferator-activated receptor β/δ (PPAR

methodsGMH model was induced by intraparenchymal injection of bacterial collagenase into the right hemispheric ganglionic eminence in P7 Sprague Dawley rats. GW0742, a PPAR

resultsResults demonstrated that endogenous protein levels of PPAR

conclusionsGW0742 inhibited mast cell-induced inflammation and improved neurobehavior after GMH, which is mediated by PPAR

Indexed as

PPAR-betaPPAR deltaAnimalsAnimals, NewbornCerebral HemorrhageChymasesHumansInflammationInterleukin-17Mast CellsRatsRats, Sprague-DawleyRNA, Small InterferingThiazolesTransforming Growth Factor beta1TryptasesChymasesInterleukin-17PPAR-betaPPAR deltaRNA, Small InterferingThiazolesTransforming Growth Factor beta1TryptasesCD300aGerminal matrix hemorrhageInflammationMast cellPPAR(β/δ)

Identifiers

PMID37995951
PMCPMC10842885
OpenAlexW4388914101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.