ArticleJournal of neuroscience methods2024
Inserting a Neuropixels probe into awake monkey cortex: two probes, two methods.
Article in Journal of neuroscience methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- A flexible quality metric for electrophysiological recordings across brain regions and species.bioRxiv : the preprint server for biology · 2026Article
- Robust minimally-invasive microfabricated stainless steel neural interfaces for high resolution recording.Nature communications · 2026Article
- High-Density Recording Reveals Sparse Clusters (But Not Columns) for Shape and Texture Encoding in Macaque V4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Developmentally stable representations of naturalistic image structure in macaque visual cortex.Cell reports · 2024Article
- A high-density 1,024-channel probe for brain-wide recordings in non-human primates.Nature neuroscience · 2024Article
- High-density recording reveals sparse clusters (but not columns) for shape and texture encoding in macaque V4.bioRxiv : the preprint server for biology · 2023Article
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6 authors at 1 institution in 2 countries.
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Abstract
backgroundNeuropixels probes have revolutionized neurophysiological studies in the rodent, but inserting these probes through the much thicker primate dura remains a challenge. NEW
methodsHere we describe two methods we have developed for the insertion of two types of Neuropixels probes acutely into the awake macaque monkey cortex. For the fine rodent probe (Neuropixels 1.0, IMEC), which is unable to pierce native primate dura, we developed a dural-eyelet method to insert the probe repeatedly without breakage. For the thicker short NHP probe (Neuropixels NP1010), we developed an artificial dura system to insert the probe. RESULTS AND COMPARISON WITH EXISTING
methodsWe have now conducted successful experiments in 3 animals across 7 recording chambers with the procedures described here and have achieved recordings with similar yields over several months in each case.
conclusionWe hope that our hardware, surgical preparation, methods for insertion and methods for removal of broken probe parts are of value to primate physiologists everywhere.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.