Evidence map›Paper›PMID 37995729›Full record

ArticleEuropean journal of dentistry2024

Gingiva Mesenchymal Stem Cells Normoxic or Hypoxic Preconditioned Application Under Orthodontic Mechanical Force on Osterix, Osteopontin, and ALP Expression.

Alexander Patera Nugraha, Ida Bagus Narmada, Ervina Restiwulan Winoto, I Gusti Aju Wahju Ardani, Ari Triwardhani, Alida Alida, Adya Pramusita, Reyhan Mahendra Nur, Nuraini Indrastie, Hui Yin Nam and 5 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Effects of Roselle (Journal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Alexander Patera NugrahaDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ida Bagus NarmadaDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ervina Restiwulan WinotoDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
I Gusti Aju Wahju ArdaniDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ari TriwardhaniDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Alida AlidaDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Adya PramusitaDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Reyhan Mahendra NurDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Nuraini IndrastieDepartment of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Hui Yin NamNanotechnology and Catalysis Research Centre (NANOCAT), Universiti Malaya, Kuala Lumpur, Malaysia.
Igo Syaiful IhsanStem Cell Research and Development Center, Universitas Airlangga, Surabaya, Indonesia.
Wibi RiawanBiomolecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.ORCID 0000-0001-5027-5051
Fedik Abdul RantamLaboratory of Immunology and Virology Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
Albertus Putera NugrahaFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID 0009-0008-5455-3387
Tengku Natasha Eleena Binti Tengku Ahmad NoorMembership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom.
Airlangga University · IDRoyal College of Surgeons of Edinburgh · GBUniversity of Brawijaya · IDUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this article was to investigate Osterix, ALP, and osteopontin expression in the compression and tension sides of alveolar bone after the application of normoxic/hypoxic-preconditioned GMSCs in rabbits ( MATERIALS AND

methodsForty-eight healthy, young male rabbits were divided into four groups: [-] OMF; [+] OMF; OMF with GMSCs normoxic-preconditioned; and OMF and GMSCs hypoxic-preconditioned. The central incisor and left mandibular molar in the experimental animals were moved, the mandibular first molar was moved mesially using nickel titanium (NiTi) and stainless steel ligature wire connected to a 50 g/mm

resultsOsterix, ALP, and osteopontin expressions were significantly different after allogeneic application of hypoxic-preconditioned GMSCs than normoxic-preconditioned GMSCs in the tension and compression of the alveolar bone side during OMF (

conclusionOsterix, ALP, and osteopontin expressions were significantly more enhanced post-transplantation of GMSCs with hypoxic-preconditioning than after transplantation of normoxic-preconditioned GMSCs in rabbits (

Identifiers

PMID37995729
PMCPMC11132784
OpenAlexW4388933763

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.