Evidence map›Paper›PMID 37995298›Full record

ArticleThe Journal of infectious diseases2024

Utility of Mycobacterium tuberculosis Genome Sequencing Snapshots to Assess Transmission Dynamics Over Time.

Courtney M Yuen, Chuan-Chin Huang, Ana Karina Millones, Roger I Calderon, Abigail L Manson, Judith Jimenez, Carmen Contreras, Ashlee M Earl, Mercedes C Becerra, Leonid Lecca and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Courtney M YuenDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-5219-2599
Chuan-Chin HuangDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ana Karina MillonesSocios En Salud Sucursal Peru, Lima, Peru.
Roger I CalderonSocios En Salud Sucursal Peru, Lima, Peru.
Abigail L MansonInfectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
Judith JimenezSocios En Salud Sucursal Peru, Lima, Peru.
Carmen ContrerasSocios En Salud Sucursal Peru, Lima, Peru.
Ashlee M EarlInfectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
Mercedes C BecerraDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Leonid LeccaDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Megan B MurrayDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Sequencing CoreU19AI109755 · NIAID · HARVARD MEDICAL SCHOOL · PI CHANDLER, DARRELL P, CULHANE, AEDIN C · 2014 to 2018
$29.1M
Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN B, VANRHIJN, ILDIKO · 2015 to 2021
$20.4M
Real-time surveillance to support dynamic and predictive models of MDR/XDR TBU19AI076217 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FARMER, PAUL EDWARD · 2007 to 2011
$13.5M
New approaches to optimizing the application and measuring the impact of community-based tuberculosis interventionsDP2MD015102 · NIMHD · BRIGHAM AND WOMEN'S HOSPITAL · PI YUEN, COURTNEY M. · 2019 to 2019
$2.4M
Epidemiology of multidrug-resistant tuberculosis in PeruU01AI057786 · NIAID · HARVARD MEDICAL SCHOOL · PI BECERRA, MERCEDES C · 2009 to 2010
$1.2M
NIAID NIH HHS U01 AI057786NIAID NIH HHS U19 AI076217NIAID NIH HHS U19 AI109755NIAID NIH HHS U19 AI110818NIAID NIH HHS U19 AI111224NIH HHS DP2MD015102NIMHD NIH HHS DP2 MD015102
6 · The paper itself

Abstract

We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru, for evaluating local transmission dynamics over time. Within a 17-km2 area, 15 of 70 (21%) isolates with WGS collected during 2011-2012 and 22 of 81 (27%) collected during 2020-2021 were clustered (P = .414), and additional isolates clustered with those from outside the area. Isolates from the later period were disproportionately related to large historic clusters in Lima from the earlier period. WGS snapshots at a sentinel site may not be useful for monitoring transmission, but monitoring the persistence of large transmission clusters might be.

Indexed as

Genome, BacterialMycobacterium tuberculosisTuberculosisWhole Genome SequencingHumansMalePerucluster analysisdisease transmissionmolecular epidemiology

Identifiers

PMID37995298
PMCPMC11095523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.