ArticleThe British journal of surgery2024
Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: plea for improved follow-up.
Article in The British journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- A blood-draw timing- and season-adjusted PTH-calcium model for predicting post-endoscopic/robotic thyroidectomy hypocalcemia.Endocrine connections · 2026Article
- Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Advanced age and differentiated thyroid carcinoma: a retrospective cohort study investigating surgical outcomes and recurrence risk.Frontiers in endocrinology · 2026Article
- Autofluorescence enhances intraoperative detection of parathyroid glands: a single-center comparative study.Frontiers in endocrinology · 2026Article
- Standardizing the reporting of postoperative hypoparathyroidism following thyroidectomy: consensus statement from the European Society of Endocrine Surgeons, the American Association of Endocrine Surgeons, and the International Association of Endocrine Surgeons.The British journal of surgery · 2025Article
- Article
- Increased risk of multisystem comorbidities and disease trajectories following hyperthyroidism: evidence from the 0.5 million UK Biobank population.Endocrine connections · 2025Article
- Development and validation of risk prediction models for permanent hypocalcemia after total thyroidectomy in patients with papillary thyroid carcinoma.Scientific reports · 2025Article
- Review
- Hypoparathyroidism after thyroidectomy: a matter of definition, experience and new adjuncts.Gland surgery · 2024Article
- Delayed cervical emphysema after thyroidectomy: a case report and a literature overview.Journal of surgical case reports · 2024Article
- Advancing parathyroid surgery: a critical examination of probe-based near-infrared autofluorescence technology.Gland surgery · 2024Article
- Prevalence of chronic postsurgical hypoparathyroidism not adequately controlled: an analysis of a nationwide cohort of 337 patients.Frontiers in endocrinology · 2024Article
- Editorial: Parathyroid disorders: updates of PTH/serum Ca2+ regulation and therapeutic prospects.Frontiers in endocrinology · 2023Article
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Abstract
backgroundA previous nationwide study from Sweden showed that the rate of permanent hypoparathyroidism is high and under-rated in the Swedish Quality Register. This retrospective population-based study aimed to validate the rate and diagnosis of permanent hypoparathyroidism found in the previous study. A secondary aim was to assess the relationship between the rate of low parathyroid hormone (PTH) levels within 24 h after surgery and the rate of permanent hypoparathyroidism.
methodsAll patients who underwent total thyroidectomy from 2005 to 2015 in a region of Sweden were included. Data were retrieved from local health records, the National Patient Registry, the Swedish Prescribed Drug Registry, and the Swedish Quality Register. A strict definition of permanent hypoparathyroidism was used, including biochemical data and attempts to stop the treatment.
resultsA total of 1636 patients were included. Altogether, 143 patients (8.7 per cent) developed permanent hypoparathyroidism. Of these, 102 (6.2 per cent) had definitive permanent hypoparathyroidism, whereas 41 (2.5 per cent) had possible permanent hypoparathyroidism, because attempts to stop the treatment were lacking (28) or patients were lost to follow-up (13). The agreement between the Swedish Quality Register and the chart review was 29.3 per cent. A proportion of 23.2 per cent with a PTH level below the reference value corresponded to a 6.7 per cent rate of permanent hypoparathyroidism.
conclusionThe risk of permanent hypoparathyroidism after total thyroidectomy is high. Some patients are overtreated because attempts to stop the treatment are lacking. Quality registers might underestimate the risk of permanent hypoparathyroidism. Approximately one-quarter of all patients with low PTH levels immediately after surgery developed permanent hypoparathyroidism.
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