Evidence map›Paper›PMID 37995088›Full record

ArticleTranslational stroke research2025

Porous Three-Dimensional Polyurethane Scaffolds Promote Scar-Free Endogenous Regeneration After Acute Brain Hemorrhage.

Qiao Zhang, Jinlin Chen, Jingjing Lin, Ruichao Liang, Min He, Yanchao Wang, Hong Tan

Abstract read
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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiao ZhangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan, China.
Jinlin ChenCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu, 610065, Sichuan, China.
Jingjing LinCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu, 610065, Sichuan, China.
Ruichao LiangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan, China.
Min HeDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan, China.
Yanchao WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan, China. wangyanchao@scu.edu.cn.
Hong TanCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu, 610065, Sichuan, China.

Funding

National Natural Science Foundation of China 52003177Sichuan Province Science and Technology Support Program 2022YFS0141
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke and is associated with significant morbidity and mortality. Despite advances in the clinical treatment of ICH, limited progress has been made regarding endogenous brain regeneration after ICH. Failure of brain regeneration is mainly attributed to the inhibitive regenerative microenvironment caused by secondary injury after ICH. In this study, we investigated a three-dimensional biodegradable waterborne polyurethane (BWPU) scaffold as a tool to promote brain regeneration after ICH. After implantation into the cavity following hematoma evacuation, these implanted scaffolds could act as a reservoir; store a series of necrotic debris, cytokines, and chemokines; and attract microglia/macrophages to their pores. Subsequently, these microglia/macrophages were polarized into the M1-like subtype to eliminate these substances. This process disperses M1-like immune cells and prevents the formation of dense glial scar-free structures after ICH. Inflammatory cells in scaffolds include scar-free secreted growth factors and extracellular matrix (ECM) proteins, and further induce a M2-like immune cells enriched regeneration-predominant microenvironment to promote endogenous brain regeneration with functional recovery. In summary, in this work, we have revealed the potential and mechanism of the BWPU scaffold as a tool to promote endogenous brain tissue regeneration after ICH.

Indexed as

Cerebral HemorrhageNerve RegenerationPolyurethanesRegenerationTissue ScaffoldsAnimalsBrainMacrophagesMaleMicrogliaPorosityPolyurethanesBrain hemorrhageBrain regenerationPolyurethaneStrokeTissue engineering scaffold

Identifiers

PMID37995088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.