Evidence map›Paper›PMID 37995073›Full record

ArticleHead and neck pathology2023

Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation.

Patricia Castro, Germán Corredor, Can Koyuncu, Luke A Nordstrom, Michelle Tiji, Taylor Leavitt, James S Lewis, Anant Madabhushi, Mitchell J Frederick, Vlad C Sandulache

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Patricia CastroDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Germán CorredorWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Can KoyuncuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Luke A NordstromMichael E. DeBakey Veterans Affairs Medical Center, ENT Section, Operative Care Line, Houston, TX, USA.
Michelle TijiMichael E. DeBakey Veterans Affairs Medical Center, ENT Section, Operative Care Line, Houston, TX, USA.
Taylor LeavittBobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, 1977 Butler Blvd. 5th Floor, Ste E5.200, Houston, TX, 77030, USA.
James S LewisDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Anant MadabhushiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Mitchell J FrederickBobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, 1977 Butler Blvd. 5th Floor, Ste E5.200, Houston, TX, 77030, USA.
Vlad C SandulacheMichael E. DeBakey Veterans Affairs Medical Center, ENT Section, Operative Care Line, Houston, TX, USA. vlad.sandulache@bcm.edu.

Funding

Improving Treatment Algorithms for Veterans with Oropharyngeal CancerIK2CX001953 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI SANDULACHE, VLAD C · 2020 to 2022
–
CSRD VA IK2 CX001953
6 · The paper itself

Abstract

objectiveOropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology.

methodsWe analyzed paired primary-recurrent OPSCC from Veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2000 and 2020 who received curative intent radiation-based treatment (with or without chemotherapy). Patient tumors were analyzed using standard immunohistochemistry and automated imaging of infiltrating lymphocytes and multinucleated tumor cells coupled to machine learning algorithms.

resultsPrimary and recurrent tumors demonstrated high concordance via p16 and p53 immunohistochemistry, with comparable levels of multinucleation. In contrast, recurrent tumors demonstrated significantly higher levels of CD8+ tumor infiltrating lymphocytes (p<0.05) and higher levels of PD-L1 expression (p<0.05).

conclusionExposure to chemo-radiation and recurrence following treatment preserves critical features of intrinsic tumor biology and the tumor immune microenvironment suggesting that novel treatment regimens may be as effective in the salvage setting as in the definitive intent setting.

Indexed as

Head and Neck NeoplasmsOropharyngeal NeoplasmsHumansLymphocytes, Tumor-InfiltratingPrognosisSquamous Cell Carcinoma of Head and NeckTumor MicroenvironmentMultinucleationOropharyngeal cancerRecurrenceTumor infiltrating lymphocytes

Identifiers

PMID37995073
PMCPMC10739687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.